© 2014

MACPF/CDC Proteins - Agents of Defence, Attack and Invasion

  • Gregor Anderluh
  • Robert Gilbert


  • A comprehensive overview of one of the largest pore forming proteins superfamilies

  • A special chapter on methodology allowing the study of mechanisms of pore formation

  • Several novel data reviews which provide new insights into the distribution of MACPF/CDC proteins throughout biology

  • In depth perspectives on MACPF/CDCs from multiple fields of study: medicine, biology, biophysics, applications-based, technical development


Part of the Subcellular Biochemistry book series (SCBI, volume 80)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Overview of MACPF/CDCs

    1. Front Matter
      Pages 1-1
    2. Gisou F. van der Goot
      Pages 3-6
    3. Gregor Anderluh, Matic Kisovec, Nada Kraševec, Robert J. C. Gilbert
      Pages 7-30
    4. Masaru Nonaka
      Pages 31-43
  3. Structures of MACPF/CDCs

  4. Functional Aspects of MACPF/CDCs

    1. Front Matter
      Pages 117-117
    2. Miša Mojca Cajnko, Miha Mikelj, Tom Turk, Marjetka Podobnik, Gregor Anderluh
      Pages 119-144
    3. Tim J. Mitchell, Catherine E. Dalziel
      Pages 145-160
    4. Omar Naneh, Tadej Avčin, Apolonija Bedina Zavec
      Pages 221-239
    5. Joana Tavares, Rogerio Amino, Robert Ménard
      Pages 241-253
    6. Lacey D. Taylor, David E. Nelson
      Pages 255-269
    7. Katja Ota, Matej Butala, Gabriella Viero, Mauro Dalla Serra, Kristina Sepčić, Peter Maček
      Pages 271-291
  5. Back Matter
    Pages 321-329

About this book


This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein superfamily that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC superfamily are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.


The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different superfamily members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.



MACPF/CDC superfamily bacterial pathogenesis biophysical approaches immunity pore forming proteins

Editors and affiliations

  • Gregor Anderluh
    • 1
  • Robert Gilbert
    • 2
  1. 1.National Institute of Chemistry, Ljubljana, SloveniaLaboratory for Molecular Biology and NanobiotechnologyLjubljanaSlovenia
  2. 2.Division of Structural BiologyUniversity of Oxford Wellcome Trust Centre for Human GeneticsOxfordUnited Kingdom

Bibliographic information

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