Advertisement

Admixture Dynamics, Natural Selection and Diseases in Admixed Populations

  • Wenfei¬†Jin

Part of the Springer Theses book series (Springer Theses)

Table of contents

About this book

Introduction

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

Keywords

African American specific high risk disease African Americans Copy Number Variation (CNV) Mendelian disease Population Admixture Single Nucleotide Polymorphism (SNP)

Authors and affiliations

  • Wenfei¬†Jin
    • 1
  1. 1.CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghaiChina

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-7408-6
  • Copyright Information Springer Science+Business Media Dordrecht 2015
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-017-7406-2
  • Online ISBN 978-94-017-7408-6
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods