© 2015

Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

  • Caroline Fonta
  • László Négyessy

Part of the Subcellular Biochemistry book series (SCBI, volume 76)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Disease Forms and Animal Models of Hypophosphatasia

  3. Expression and Regulation of TNAP in the Central Nervous System

    1. Front Matter
      Pages 59-59
    2. Caroline Fonta, Pascal Barone, Laia Rodriguez Martinez, László Négyessy
      Pages 85-106
    3. Orsolya Kántor, Dorottya Cserpán, Béla Völgyi, Ákos Lukáts, Zoltán Somogyvári
      Pages 107-123
    4. Barbara Deracinois, Anne-Marie Lenfant, Marie-Pierre Dehouck, Christophe Flahaut
      Pages 125-151
  4. TNAP Functions in the Nervous System

    1. Front Matter
      Pages 153-153
    2. Myriam Ermonval, Florence Baychelier, Caroline Fonta
      Pages 167-183
    3. László Négyessy, Balázs Györffy, János Hanics, Mihály Bányai, Caroline Fonta, Fülöp Bazsó
      Pages 185-205
    4. Stephen P. Coburn
      Pages 207-238
    5. Sarah E. Street, Nathaniel A. Sowa
      Pages 283-305
  5. TNAP in Neurological Disorders

    1. Front Matter
      Pages 307-307
    2. Takeshi Taketani
      Pages 309-322
    3. Christine Hofmann, Franz Jakob, Lothar Seefried, Birgit Mentrup, Stephanie Graser, Horacio Plotkin et al.
      Pages 323-341

About this book


Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.


Brain development Cerebral cortex Epilepsy Metabolic disorders Neurobiology

Editors and affiliations

  • Caroline Fonta
    • 1
  • László Négyessy
    • 2
  1. 1.National Centre for Scientific Research (CNRS), University of Toulouse-UPSToulouseFrance
  2. 2.Wigner Research Centre for PhysicsHungarian Academy of SciencesBudapestHungary

Bibliographic information

Industry Sectors
Health & Hospitals