Signal Transducers and Activators of Transcription (STATs)

Activation and Biology

  • Pravin B. Sehgal
  • David E. Levy
  • Toshio Hirano

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Introduction: A Brief History of the STATs and a Glance at the Future

  3. STAT Proteins and Their Regulators

    1. Front Matter
      Pages 9-9
    2. Markus H. Heim
      Pages 11-26
    3. Pipsa Saharinen, Olli Silvennoinen
      Pages 27-42
    4. Peter C. Heinrich, Iris Behrmann, Serge Haan, Heike M. Hermanns, Gerhard Müller-Newen, Fred Schaper
      Pages 43-53
    5. Robyn Starr, Douglas J. Hilton
      Pages 55-73
    6. Bin Liu, Ke Shuai
      Pages 75-85
    7. Erika A. Bach, Norbert Perrimon
      Pages 87-104
    8. Jeffrey G. Williams
      Pages 105-121
    9. Andrew C. Oates, Leonard I. Zon
      Pages 123-134
  4. Mechanisms of Activation of and Transcriptional Regulation by STAT Proteins

    1. Front Matter
      Pages 135-135
    2. Christian Schindler, Li Song
      Pages 137-154
    3. Jason H. Kurzer, Christin Carter-Su
      Pages 177-190
    4. José Miguel Rodríguez-Frade, Mario Mellado, Carlos Martínez-A.
      Pages 191-206
    5. Thomas Decker, Mathias Müller, Pavel Kovarik
      Pages 207-222
    6. Corinne M. Silva, Julie L. Boerner, Sarah J. Parsons
      Pages 223-236
    7. Pravin B. Sehgal, Mehul Shah
      Pages 247-267

About this book


The year 2003 marks the tenth anniversary of the first use of the acronym "Stat" (also written "STAT") in the scientific literature for a family of transcription factors which rapidly transduce cytokine-and growth factor­ elicited signals from the plasma membrane to the cell nucleus thereby activating gene transcription (thus, . s. ignal Transducers and Activators of Transcription). From those beginnings, the field of STAT transcription factors, their related regulatory molecules and their biology has grown exponentially in many different directions. In recognition of the rapid growth and broad scope of the STAT transcription factor field today, and to celebrate the tenth anniversary of the use of this term in the scientific literature, Kluwer Academic Publishers B. V. requested us to compile a volume on STAT transcription factors that could serve as an overview of this burgeoning area. Thus, we wanted a volume that would serve as a reference for what is known about STAT proteins and their biology, would describe the current state of ongoing research in this broad area, and would look toward the future to try to predict the discoveries that lie ahead. Our charge was to seek out the very best experts in the field and to coax them to briefly summarize their areas of expertise.


Activation Translation Viruses Vivo biological functions conservation gene expression gene transcription genetics proteins regulation transcription

Editors and affiliations

  • Pravin B. Sehgal
    • 1
  • David E. Levy
    • 1
  • Toshio Hirano
    • 2
  1. 1.New York University School of MedicineUSA
  2. 2.Osaka UniversityJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 2003
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-6421-9
  • Online ISBN 978-94-017-3000-6
  • About this book
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