Homocysteine and Vascular Disease

  • Killian Robinson

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 230)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Ian Graham, Killian Robinson
    Pages 1-4
  3. Donald W. Jacobsen
    Pages 15-39
  4. Johan B. Ubbink, Rhena Delport
    Pages 41-57
  5. Per Magne Ueland, Helga Refsum, Jørn Schneede
    Pages 59-84
  6. Peter W. F. Wilson, Paul F. Jacques
    Pages 85-95
  7. Kilmer S. McCully
    Pages 97-116
  8. Paolo Rubba, Giovanni Di Minno, Generoso Andria
    Pages 117-133
  9. Ahmed M. Abou-Zamzam Jr., Gregory L. Moneta, John M. Porter, Lloyd M. Taylor Jr.
    Pages 135-149
  10. P. Barton Duell, M. René Malinow
    Pages 173-202
  11. Martin Den Heijer
    Pages 239-252
  12. Killian Robinson, Vincent W. Dennis
    Pages 253-270

About this book

Introduction

This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta­ bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo­ lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.

Keywords

cardiovascular coronary artery disease coronary heart disease heart disease molecular biology stroke vascular disease

Editors and affiliations

  • Killian Robinson
    • 1
  1. 1.Department of CardiologyThe Cleveland Clinic FoundationClevelandUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-1789-2
  • Copyright Information Springer Science+Business Media B.V. 2000
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-5431-9
  • Online ISBN 978-94-017-1789-2
  • Series Print ISSN 0166-9842
  • About this book
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