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Abnormal Embryogenesis

Cellular and Molecular Aspects

  • Editors
  • T. V. N. Persaud

Part of the Advances in the Study of Birth Defects book series (ASBD, volume 3)

Table of contents

  1. Front Matter
    Pages i-ix
  2. R. G. Skalko, S. M. Tucci, R. H. Dropkin
    Pages 15-27
  3. R. M. Pratt, A. A. Figueroa, R. M. Greene, Ann L. Wilk, D. S. Salomon
    Pages 161-176
  4. B. Menkes, Oltea Prelipceanu, I. Capalnaşan
    Pages 219-241
  5. Back Matter
    Pages 243-246

About this book

Introduction

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intrauterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms, and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The comributions in this volume include some of the more recent and exciting observations on the cellular and molecular aspects of developmental defects. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Keywords

adaptation animals development embryo mouse nutrition

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-6654-6
  • Copyright Information Springer Science+Business Media B.V. 1979
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6656-0
  • Online ISBN 978-94-011-6654-6
  • Buy this book on publisher's site
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Biotechnology