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Teratological Testing

  • T. V. N. Persaud

Part of the Advances in the Study of Birth Defects book series (ASBD, volume 2)

Table of contents

  1. Front Matter
    Pages i-x
  2. A. G. Hendrickx, P. E. Binkerd
    Pages 1-23
  3. S. Sandor, Maria Checiu
    Pages 69-94
  4. H. Spielmann, H.-G. Eibs, Ursula Jacob-Müller
    Pages 95-112
  5. H.-G. Eibs, H. Spielmann, Margret Hägele, J. Klose
    Pages 113-137
  6. R. D. Hood
    Pages 191-210
  7. A. R. Beaudoin
    Pages 211-222
  8. L. A. Kennedy, T. V. N. Persaud
    Pages 223-238
  9. M. R. Sikov, B. P. Hildebrand
    Pages 267-291
  10. Back Matter
    Pages 353-357

About this book

Introduction

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mec.;hanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The· contributions in this volume deal primarily with the areas of terato­ logical evaluation and the use of selected animal models for the study of con­ genital anomalies. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Keywords

animals development embryo mouse nutrition

Editors and affiliations

  • T. V. N. Persaud
    • 1
  1. 1.Department of Anatomy Faculties of Medicine and DentistryUniversity of ManitobaWinnipegCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-6651-5
  • Copyright Information Springer Science+Business Media B.V. 1979
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6653-9
  • Online ISBN 978-94-011-6651-5
  • Buy this book on publisher's site
Industry Sectors
Biotechnology