HDL Deficiency and Atherosclerosis

  • G. Assmann

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 174)

Table of contents

  1. Front Matter
    Pages i-x
  2. H. Funke, H. Wiebusch, S. Rust, G. Assmann
    Pages 1-15
  3. A. von Eckardstein, Y. Huang, G. Assmann
    Pages 17-23
  4. J. C. Fruchart, C. De Geteire, B. Delfy, G. R. Castro
    Pages 25-28
  5. B. G. Brown, Xue-Qiao Zhao, V. M. G. Maher, A. Chait, M. Cheung, L. D. Fisher et al.
    Pages 29-42
  6. U. Seedorf, P. Brysch, T. Engel, S. Scheek, M. Raabe, M. Fobker et al.
    Pages 43-52
  7. N. Maeda, S. H. Zhang, R. L. Reddick
    Pages 61-66
  8. H. B. Brewer Jr, D. R. Brown, V. S. Kashyap, D. Applebaum-Bowden, J. M. Hoeg, N. Maeda et al.
    Pages 67-80
  9. Back Matter
    Pages 81-84

About this book

Introduction

The tandem pace of medical knowledge and prevention of ischaemic heart disease over the past 50 years is testimony to the effectiveness of a combination of massive scientific research, continuous transfer of the results to medical practice, community actions and population aware­ ness. The death rate from coronary heart disease in the United States rose 20% from 1950 to 1963, when a dramatic and steady downward inflection began, arriving today at a rate over 50% lower. Numerous factors have contributed to this success. By 1950 lipoproteins had just been discovered, but a decade later a great surge in research had focussed upon plasma cholesterol and lipoprotein concentrations as major predictors of risk. Today, a continuing expansion and sophistica­ tion of that research has removed all doubt about the significance of particular patterns. The pathway to ideal prophylaxis, however, particu­ larly for risks associated with inherited lipoprotein disorders, still awaits the untangling of great amounts of new information that continue to rise from application of molecular technology. This volume deals with many of the contemporary puzzles. One theme revolves about the high density lipoproteins. For twenty years the HDL have been considered a defence against the caprices of the LDL, now believed to be particularly villainous after oxidation.

Keywords

Lipoprotein atherosclerosis cardiovascular coronary heart disease gene therapy genetics heart heart disease high-density lipoprotein (HDL)

Editors and affiliations

  • G. Assmann
    • 1
  1. 1.Institut für ArterioskleroseforschungWestfalische Wilhelms-UniversitätMünsterGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-6585-3
  • Copyright Information Springer Science+Business Media B.V. 1995
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6587-7
  • Online ISBN 978-94-011-6585-3
  • Series Print ISSN 0166-9842
  • About this book
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