The Dynamic Body Tissues

An account of the chalone mechanisms and other influences that control the epidermis and the various body tissues, and of the failure of these mechanisms in cancer

  • William S. Bullough

Table of contents

  1. Front Matter
    Pages i-viii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. William S. Bullough
      Pages 3-14
  3. The Dynamic Epidermis

    1. Front Matter
      Pages 15-15
    2. William S. Bullough
      Pages 17-39
    3. William S. Bullough
      Pages 40-53
    4. William S. Bullough
      Pages 54-73
    5. William S. Bullough
      Pages 74-80
  4. Homeostasis in Other Tissues

    1. Front Matter
      Pages 81-81
    2. William S. Bullough
      Pages 83-99
    3. William S. Bullough
      Pages 100-105
    4. William S. Bullough
      Pages 106-123
  5. The Failure of Homeostasis

    1. Front Matter
      Pages 125-125
    2. William S. Bullough
      Pages 127-150
  6. Envoi

    1. Front Matter
      Pages 151-151
    2. William S. Bullough
      Pages 153-165
  7. Back Matter
    Pages 167-181

About this book


The study of life is the study of tier upon tier of interlocking homeostatic mechanisms, and the main theme of this book concerns that part of the system that ensures cellular and tissue homeostasis and thus maintains tissue mass, tissue structure and tissue function in the adult mammal. The functional existence of any adult tissue depends on the continuing control of the states of differentiation of its cells. Just as in an embryo, where cellular differentiation is initiated and controlled by the genetic responses of the cells to specific messenger molecules, so also throughout the whole of adult life does the genetic activity of the tissue cells continue to be regulated by similarly specific messenger molecules. The process of differentiation does not cease in the embryo but remains as the essential factor which ensures not only the function but also the continuing existence of the adult tissues. Thus the first problem considered here, the methods of control of cell production, cell function and cell death, is discussed in terms of the nature and mode of action of those messenger molecules which, from moment to moment, determine the states of differentiation of the tissue cells. Some of these messenger molecules are synthesized in adjacent tissues while others are synthesized within the responding tissues themselves.



Authors and affiliations

  • William S. Bullough
    • 1
  1. 1.University of LondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1983
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6263-0
  • Online ISBN 978-94-011-6261-6
  • Buy this book on publisher's site
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