Multiple Risk Factors in Cardiovascular Disease

Strategies of Prevention of Coronary Heart Disease, Cardiac Failure, and Stroke

  • Antonio M. GottoJr.
  • C. Lenfant
  • Rodolfo Paoletti
  • A. L. Catapano
  • A. S. Jackson

Part of the Medical Science Symposia Series book series (MSSS, volume 12)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Plasma Lipids and Lipoproteins

    1. Johan Auwerx, Jean Dallongeville, Jean-Charles Fruchart, Bart Staels
      Pages 9-17
    2. R. Paoletti, F. Bernini, A. Corsini, M. Soma
      Pages 19-24
  3. Coagulation, Fibrinolysis, and Platelet Inhibition

  4. Emerging Risk Factors for Cardiovascular Disease

    1. Edzard Ernst, Wolfgang Koenig
      Pages 75-84
    2. Irène Juhan-Vague, Marie Christine Alessi
      Pages 85-92
  5. Risk Factors and Intervention: National Initiatives

  6. LDL Oxidation, Antioxidants, and Atherosclerosis

  7. Diabetes

About this book


This volume is a collection of the most significant contributions to the 4th International Symposium on MULTIPLE RISK FACTORS IN CARDIOVASCULAR DISEASE: STRATEGIES OF PREVENTION OF CORONARY HEART DISEASE, CARDIAC F AlLURE, AND STROKE held in Washington, D. C. in April 1997. The meeting focused on the risk factors for cardiovascular disease and their interactions. The need for this symposium is based on the epidemiological, clinical, and biological evidence that individuals from industrialized countries often possess two or more risk factors which synergistically increase the global risk profile. This has become more evident in recent years with the increase in life expectancy of populations in the industrialized countries. The evidence that a combination of risk factors confers a very high risk of developing cardiovascular diseases, is of pivotal interest in the process of detection of patients who will benefit the most from pharmacological treatment. Many recent epidemiological data identifying the intrinsic and environmental factors contributing to the development of atherosclerosis are discussed. These results, in parallel with basic and clinical research, underline atherosclerosis as a complex and multifactorial process involving the influences of lipids, including lipoprotein subfractions, blood pressure rheologic forces, carbohydrate tolerance, and thrombogenic factors, including fibrinogen, tissue factor, PAl-I, and homocysteine. Furthennore, the risk associated with anyone of these risk factors varies widely depending on the level of the associated atherogenic risk factors. Hyper­ cholesterolemia and hypertriglyceridemia, for instance, are more common than would be expected by chance among hypertensive patients.


Diabetes Lipoprotein atherosclerosis cardiovascular heart hypertension stroke vascular disease

Editors and affiliations

  • Antonio M. GottoJr.
    • 1
  • C. Lenfant
    • 2
  • Rodolfo Paoletti
    • 3
  • A. L. Catapano
    • 3
  • A. S. Jackson
    • 4
  1. 1.Cornell University Medical CollegeNew YorkUSA
  2. 2.National Heart, Lung, and Blood InstituteNIHBethesdaUSA
  3. 3.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  4. 4.Giovanni Lorenzini Medical FoundationHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 1998
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6108-7
  • Online ISBN 978-94-011-5022-4
  • Series Print ISSN 0928-9550
  • About this book
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