Multiple Risk Factors in Cardiovascular Disease

  • Antonio M. GottoJr.
  • Claude Lenfant
  • Rodolfo Paoletti
  • Maurizio Soma

Part of the Medical Science Symposia Series book series (MSSS, volume 1)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. M. Laurenzi, R. Stamler, M. Mancini, M. Cirillo, M. Trevisan, E. Farinaro et al.
    Pages 31-37
  3. G. Crepaldi, S. Maggi, G. Baggio
    Pages 39-48
  4. Steven E. Reis, Sidney O. Gottlieb
    Pages 49-67
  5. G. S. Berenson, S. R. Srinivasan, L. S. Webber
    Pages 69-81
  6. Gerald M. Reaven
    Pages 91-97
  7. R. R. Williams, S. C. Hunt, P. N. Hopkins, S. J. Hasstedt, L. L. Wu, B. M. Stults et al.
    Pages 111-115
  8. Michael A. Weber, David H. G. Smith, Joel M. Neutel, William F. Graettinger
    Pages 133-140
  9. Gordon H. Williams, Norman K. Hollenberg
    Pages 141-146
  10. M. D. Guazzi, F. Fabbiocchi, P. Ravagnani, S. Cozzi, A. Apostolo, P. Sganzerla et al.
    Pages 159-163
  11. Norman K. Hollenberg
    Pages 165-172
  12. E. Tremoli, S. Eligini, R. Paoletti
    Pages 201-207
  13. Richard B. Devereux, Michael J. Koren, Mary J. Roman, John H. Laragh
    Pages 209-214
  14. William P. Castelli
    Pages 225-228
  15. Melissa A. Austin
    Pages 229-233
  16. Cesare R. Sirtori
    Pages 247-254
  17. A. Gaw, B. A. Griffin, M. J. Caslake, C. J. Packard, J. Shepherd
    Pages 255-258
  18. Back Matter
    Pages 265-268

About this book


This book includes the most significant contributions of the First International Symposium on "Multiple risk factors in cardiovascular disease", chaired by Professors A. V. Chobanian (Boston), A. M. Gotto Jr. (Houston), c. Lenfant (Bethesda), R. Paoletti and A. Zanchetti (Milan), held in Washington DC, 10-12 December 1990, which focused on the risk factors for cardiovascular disease and their interactions. The need for this symposium is based on the epidemiological evidence that individuals from industrialized countries often possess two or more risk factors which synergically increase the global risk profile. The evidence that isolated vascular risk factors are not commonly found in high risk patients but more often a combination of risk factors are detected, is highlighted. Many recent epidemiological data identifying the intrinsic and environ­ mental factors contributing to the development of atherosclerosis are discussed. These results, in parallel to basic and clinical research, underline how atherosclerosis is a complex and multifac­ torial process involving the influences of lipid deposition, blood pressure, rheologic forces, carbohydrate tolerance, and thrombogenic factors (fibrinogen and platelets). Atherosclerosis is markedly accelerated by other risk factors, more so in the presence of concomitant hypercholes­ terolemia, hypertension, diabetes, upper body obesity. Furthermore, the risk associated with anyone of these risk factors varies widely depending on level of the associated atherogenic risk factors.


Diabetes Internist cardiovascular hypertension insulin pathophysiology physiology

Editors and affiliations

  • Antonio M. GottoJr.
    • 1
  • Claude Lenfant
    • 2
  • Rodolfo Paoletti
    • 3
  • Maurizio Soma
    • 3
  1. 1.Baylor College of Medicine and The Methodist HospitalHoustonUSA
  2. 2.National Heart, Lung, and Blood InstituteNIHBethesdaUSA
  3. 3.Institute of Pharmacological SciencesUniversity of MilanMilanItaly

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1992
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-5196-5
  • Online ISBN 978-94-011-2700-4
  • Series Print ISSN 0928-9550
  • Buy this book on publisher's site
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Internal Medicine & Dermatology