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Amino Acids

Chemistry, Biology and Medicine

  • Book
  • © 1990

Overview

Editors:
  1. Gert Lubec

    1. Department of Pediatrics, University of Vienna, Vienna, Austria

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    You can also search for this editor in PubMed   Google Scholar

  2. Gerald A. Rosenthal

    1. T. H. Morgan School of Biological Sciences and The Graduate Center for Toxicology, University of Kentucky, Lexington, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (147 chapters)

  1. Basic chemistry, Analysis and Synthesis

    1. Enantioseparation of Cα-disubstituted glycines

      • Hans Brückner, Mathias Langer, Ali Esna-Ashari, Anik Labudda, Zbigniew J. KamiÅ„ski, Miroslaw T. Leplawy et al.
      Pages 159-165

    2. Enzymatic synthesis and biochemical reactions of fluorinated analogues of L-tyrosine and L-dopa

      • Robert S. Phillips, Robert L. Von Tersch, Joel G. Fletcher, Ah H. Lai
      Pages 166-172

    3. The presence of 4-methylproline in the mammalian system

      • I. Graef, B. Bartosch, Chr. Prusa, J. Häusler, G. Lubec
      Pages 173-183

    4. Infrared spectroscopical studies on the non-enzymatic glycosylation of arginine and collagen

      • K. Kranewitter, G. Lubec
      Pages 184-192

    5. Biosynthesis of epidermal growth factor having nonprotein amino acid residues by Escherichia coli

      • Hiroshi Koide, Mitsuko Oishi, Takanori Oka, Tetsuo Miyake, Toru Fuwa, Shigeyuki Yokoyama et al.
      Pages 193-200

    6. Determination of methylated basic amino acids, 5-hydroxylysine, and elastin crosslinks in proteins and tissues

      • Constantinos G. Zarkadas, Edward A. Meighen, James A. Rochemont, George C. Zarkadas, Ali D. Khalili, Quang Nguyen
      Pages 201-216

  2. Neurochemistry/Neurobiology

    1. Front Matter

      Pages 217-217
      Download chapter PDF

    2. Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists

      • Astrid G. Chapman, Jeanette H. Swan, Smita Patel, Joanne L. Graham, Brian S. Meldrum
      Pages 219-232

    3. Differential effects of competitive and noncompetitive NMDA receptor antagonists on GABA turnover in the mouse brain

      • Raymond Bernasconi, Therese Leonhardt, Pierre Martin, Anne F. Steulet, Chantai Portet, Kurt Stöcklin et al.
      Pages 233-243

    4. Excitatory amino acid receptors coupled to phosphoinositide metabolism: Characterization and possible role in physiology and physiopathology

      • M. Récasens, J. Guiramand
      Pages 244-254

    5. Excitatory amino acid actions on membrane potential and conductance of brainstem motoneurones

      • J. Durand, J. P. Gueritaud
      Pages 255-262

    6. Blockade of audiogenic seizures by a GABA-uptake inhibitor, NO-328, in the genetically epilepsy-prone rat

      • Carl L. Faingold, Marcus E. Randall, Catherine A. Copley
      Pages 263-268

    7. N-Methyl-D-aspartate antagonists stimulate locomotor activity in monoamine depleted rats: Implications for the therapy of Parkinson’s disease

      • Thomas Klockgether, Lechoslaw Turski, Peter Andreas Löschmann, Helmut Wachtel
      Pages 269-275

    8. Motor neuron degeneration linked to excitatory amino acids: Histological and immunocytochemical approaches

      • J. Hugon, J. M. Vallat, P. S. Spencer, D. Barthe
      Pages 276-280

    9. Acromelic acid as a tool for the study of specific neurone damages

      • H. Shinozaki, M. Ishida, Y. Gotoh, S. Kwak
      Pages 281-293

    10. Studies on the role of NMDA, GABA and adenosine receptors within discrete brain nuclei in the high pressure neurological syndrome in rats

      • Maria H. Millan, Bridget Wardley-Smith, Michael J. Halsey, Brian S. Meldrum
      Pages 294-302

    11. Cerebral amino acids in neonate from caffeine-drinking dam

      • H. Tanaka, M. Arima
      Pages 303-306

    12. Inhibitory effects of L-threo-3,4-dihydroxyphenylserine against maximal electroconvulsion and brain norepinephrine in mice

      • Motoaki Yoshida, Kazuo Yoshizawa, Takao Nakanishi
      Pages 307-317

    13. Small neurons in the lower spinal cord are selectively damaged in the spastic rat by acromelic acid

      • S. Kwak, H. Aizawa, M. Ishida, Y. Gotoh, H. Shinozaki
      Pages 318-326

    14. Alteration of the NMDA associated ion channel binding sites in the epileptic mutant mouse quaking

      • Yves Maurin, Marie Jo Besson, Nadia Mitrovic
      Pages 327-336
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Keywords

About this book

There is little wonder in the fact that the investigation of amino acids is of fundamental interest to scientists from so many diversified fields. If amino acids were only basic constituents of enzymes as well as structural and other proteins, this property alone would elevate them to real scientific importance. Added to this role, however, is their ability to serve as building blocks for the production of many classes of secondary metabolites. They can support the biosynthesis of a myriad of natural products including nonprotein amino acids, cyanogenic glycosides, phar­ macologically active alkaloids, certain phenols, purines and pyrimidines, nucleic acids, condensed tannins, lignins and other metabolites. The approximately twenty or so amino (and imino) acids that comprise proteins are well known; less familiar are what is now approaching 600 nonprotein amino acids that have been isolated and characterized from plant, fungal or animal sources. Investigations of the protein amino acids have proven of outstanding value in enhancing our understanding of a variety of physiological and neurological topics that affect human health and well being. Amino acids are used to probe inhibitory and excitatory transmission receptors in the brain. They contribute to our understanding of epilepsy, development of anti-epileptic drugs, production of novel y-arninobutyric acid uptake inhibitors, and acute and chronic neurodegenera­ tive disorders.

Editors and Affiliations

  • Department of Pediatrics, University of Vienna, Vienna, Austria

    Gert Lubec

  • T. H. Morgan School of Biological Sciences and The Graduate Center for Toxicology, University of Kentucky, Lexington, USA

    Gerald A. Rosenthal

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