From Cell Biology to Pharmacology and Therapeutics

  • P. M. Vanhoutte
  • P. R. Saxena
  • R. Paoletti
  • N. Brunello
  • A. S. Jackson

Part of the Medical Science Symposia Series book series (MSSS, volume 5)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Molecular and Cell Biology

    1. Jean C. Shih, Qin-Shi Zhu, Joseph Grimsby, Kevin Chen, Jack Shih
      Pages 1-8
    2. Beth J. Hoffman
      Pages 9-19
    3. P. Hartig, N. Adham, J. Bard, A. Hou-yu, H.-T. Kao, M. Macchi et al.
      Pages 21-31
  3. Pharmacology of Serotonin Receptors

    1. P. P. A. Humphrey, P. Hartig, D. Hoyer
      Pages 41-47
    2. P. Blier, G. Piñeyro, T. Dennis, C. De Montigny
      Pages 55-63
      Pages 65-71
    4. D. N. Middlemiss, M. S. Beer, L. O. Wilkinson
      Pages 73-84
    5. D. Hoyer, A. T. Bruinvels, J. M. Palacios
      Pages 85-97
    6. GJ. Kilpatrick, H. Rogers
      Pages 99-106
    7. David E. Clarke, Joel Bockaert
      Pages 107-117
    8. P. A. J. Janssen, H. Moereels
      Pages 119-126
  4. Central Cardiovascular Effects and Migraine

    1. Alberto J. Kaumann, Andrew D. Medhurst, Penny Boyland, Mythily Vimal, Rodney C. Young
      Pages 135-139
    2. N. Kolassa, K. D. Beller, R. Boer, H. Boss, K. H. Sanders
      Pages 151-157
  5. Prevention of Emesis

    1. B. Costall, R. J. Naylor, J. A. Rudd
      Pages 165-170
    2. U. Wells, M. Ravenscroft, P. Bhandari, P. L. R Andrews
      Pages 179-186
  6. Prevention of Emesis

    1. S Z Langer, D Graham
      Pages 197-204
    2. Berend Olivier, Jan Mos, Ellen Molewijk, Theo Zethof, Guus Van Der Poel
      Pages 205-210
    3. Ronald M. Salomon, Helen L. Miller, Pedro L. Delgado, Dennis S. Charney
      Pages 211-222
    4. D. L. Murphy, A. Broocks, C. Aulakh, T. A. Pigott
      Pages 223-230
    5. H. G. M. Westenberg, J. A. Den Boer
      Pages 249-254
  7. Schizophrenia

    1. T. H. Svensson, G. G. Nomikos, J. L. Andersson
      Pages 263-270
    2. Becky L. Kinkead, Michael J. Owens, Charles B. Nemeroff
      Pages 289-296
  8. Vascular Function

    1. J. A. Angus, T. M. Cocks, M. Ross-Smith
      Pages 297-305
    2. C. J. Vrints, J. Bosmans, H. Bult, A. G. Herman, J. P. Snoeck
      Pages 321-328
  9. Regulation of the Immune System

    1. G. Fillion, M.-P. Fillion, I. Cloez-Tayarani, H. Sarhan, F. Haour, F. Bolanos
      Pages 329-335
    2. Kristoffer Hellstrand, Claes Dahlgren, Svante Hermodsson
      Pages 345-351
    3. J. Clancy, G. Fillion, K. Hellstrand, S. A. Lorens
      Pages 353-357
  10. 5–ht Mechanisms in Drug Abuse

    1. H. Lal, S. M. Rezazaden, C. J. Wallis
      Pages 367-374
    2. W. J. Mcbride, J. M. Murphy, L. Lumeng, T.-K. Li
      Pages 375-381
  11. 5–ht Mechanisms in Drug Abuse

    1. G. Curzon, E. L. Gibson, A. J. Kennedy, A. O. Oluyomi
      Pages 393-399
  12. Neuroproptection, Sleep, and Memory

    1. J. Traber, K. M. Bode-Greuel, E. Horvath
      Pages 401-405
    2. B. Costall, M. A. Domeney, M. E. Kelly, R. J. Naylor
      Pages 407-416

About this book


This volume contains the Proceedings of the invited lectures of the Second International Sym­ posium on SEROTONIN from Cell Biology to Pharmacology and Therapeutics held in Houston, Texas September 15-18, 1992. The meeting was held under the co-sponsorship of the Serotonin Club, the Giovanni Lorenzini Medical Foundation, and the Fondazione Giovanni Lorenzini. This volume discusses the major exploration in knowledge that has occurred recently of the complex role that 5- hydroxytryptamine (serotonin) plays in health and disease. In par­ ticular, these Proceedings highlight major breakthroughs in molecular biology and classification of receptor subtypes that are responsible for the many actions of the monoamine. The ever­ increasing importance of serotonin in central regulation, whether autonomic or behavioral is represented by a large number of chapters prepared by world experts. Additionally, the role of serotonin in peripheral organs is also discussed. Hence, this volume provides the reader with a unique, up-to-date review of this exciting and novel area of science. These Proceedings obviously are of great interest, not only to the researchers directly engaged in the quest for the understanding and unraveling of the actions of the interactions with serotonin as a major neurohumoral mediator, but also to all scholars and clinicians who wish to acquire a better understanding of the functioning of the brain and of peripheral organs. Since this volume was constructed as a compilation of invited lectures, the scientific content and the opinions expressed in the chapters are the sole responsibility of the authors.


biology cell cell biology depression drug drug abuse memory neuroprotection receptor regulation research schizophrenia serotonin

Editors and affiliations

  • P. M. Vanhoutte
    • 1
  • P. R. Saxena
    • 2
  • R. Paoletti
    • 3
  • N. Brunello
    • 4
  • A. S. Jackson
    • 5
  1. 1.Baylor College of MedicineHoustonUSA
  2. 2.Department of PharmacologyErasmus UniversityRotterdamThe Netherlands
  3. 3.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  4. 4.University of ModenaDepartment of Pharmaceutical SciencesModenaItaly
  5. 5.Giovanni Lorenzini Medical FoundationHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 1993
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4849-1
  • Online ISBN 978-94-011-1920-7
  • Series Print ISSN 0928-9550
  • Buy this book on publisher's site
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