Calcium Antagonists

Pharmacology and Clinical Research

  • T. Godfraind
  • R. Paoletti
  • S. Govoni
  • P. M. Vanhoutte

Part of the Medical Science Symposia Series book series (MSSS, volume 3)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Calcium Channels, The Molecular Approach

    1. Olga Krizanova, Philippe Lory, Arnold Schwartz
      Pages 1-8
    2. M. M. Hosey, R. M. Brawley, C. F. Chang, L. M. Gutierrez, J. Ma, E. Rios et al.
      Pages 9-14
  3. Cardiovascular Applications of Calcium Antagonists: From Pathophysiology to Therapy

    1. Hypertension and Heart Failure

    2. Atherosclerosis

      1. Thomas N. Tulenko, R. Preston Mason, Meng Chen, Hiromi Tasaki, Daniel Rock, David Stepp
        Pages 107-115
      2. R. Paoletti, M. Raiteri, M. Soma, F. Bernini
        Pages 125-132
      3. F. Bernini, A. Corsini, M. Mazzotti, S. Bellosta, M. Soma, R. Paoletti
        Pages 157-164
      4. John D. Folts, Jonathan W. Hamilton, Charles K. Stone
        Pages 165-171
      5. R. Donnelly, A. D. Morris, J. M. C. Connell, J. L. Reid
        Pages 173-177
  4. Calcium Channels and Calcium Antagonists in Neurobiology and Nervous Disorders

    1. H. Reuter, B. F. X. Reber, M. M. Usowicz, H. Porzig
      Pages 183-188
    2. Alessandra Nori, Adelina Martini, Pompeo Volpe
      Pages 195-203
    3. Leif Hertz, William E. Code
      Pages 205-213
    4. Stanley L. Cohan, Rena Getz, Mei Chen
      Pages 215-220
    5. R. Bangalore, J. Ferrante, M. Hawthorn, W. Zheng, A. Rutledge, M. Gopalakrishnan et al.
      Pages 221-229
    6. Fiorenzo Battaini, Marco Trabucchi, Valerian Chikvaidze, Stefano Govoni
      Pages 231-240
    7. M. Borgers, L. Ver Donck, H. Geerts
      Pages 241-247
    8. P. Gaetani, R. Rodriguez y Baena, D. Lombardi, F. Marzatico, R. Bellazzi, S. Quaglini et al.
      Pages 249-255
    9. J. Gheuens, M. De Ryck, J. Van Reempts, T. Peters
      Pages 257-263
    10. C. Fieschi, D. Toni, M. Frontoni, M. Fiorelli, M. L. Sacchetti, C. Argentino et al.
      Pages 265-270
    11. Fredric B. Meyer
      Pages 271-277
  5. Novel Applications and Aspects of Calcium Antagonist Pharmacology

  6. Back Matter
    Pages 377-381

About this book


Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades.
As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally.
This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.


atherosclerosis calcium cardiovascular clinical research drug resistance heart hypertension pathophysiology physiology research resistance

Editors and affiliations

  • T. Godfraind
    • 1
  • R. Paoletti
    • 2
  • S. Govoni
    • 2
  • P. M. Vanhoutte
    • 3
  1. 1.Laboratory of PharmacologyCatholic University of LouvainBrusselsBelgium
  2. 2.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  3. 3.Center for Experimental TherapeuticsBaylor Institute of MedicineHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 1993
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4756-2
  • Online ISBN 978-94-011-1725-8
  • Series Print ISSN 0928-9550
  • Buy this book on publisher's site
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