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Calcium: The molecular basis of calcium action in biology and medicine

  • Book
  • © 2000

Overview

Editors:
  1. Roland Pochet

    1. Université Libre de Bruxelles, Belgium

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  2. Rosario Donato
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  3. Jacques Haiech
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  4. Claus Heizmann
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  5. Volker Gerke
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Table of contents (42 chapters)

  1. Calcium Related Diseases

    1. Front Matter

      Pages 305-305
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    2. Annexinopathies

      • Harvey B. Pollard, Meera Srivastava
      Pages 307-316

    3. Autoimmune Disease and Calcium Binding Proteins

      • P. Eggleton, D. H. Llewellyn
      Pages 317-331

    4. Calcium Antagonists and Calcium Sensitizers

      • P. A. van Zwieten
      Pages 333-363

    5. Calcium-Binding Proteins in Type I Allergy: Elicitors and Vaccines

      • Rudolf Valenta, Anna Twardosz, Ines Swoboda, Brigitte Hayek, Susanne Spitzauer, Dietrich Kraft
      Pages 365-377

    6. Calcium Channelopathies in Nervous System

      • Daniela Pietrobon
      Pages 379-400

    7. Calcium and Diabetes

      • Shahidul Islam
      Pages 401-413

    8. Inherited and Acquired Disorders of Extracellular Calcium (Ca 0 2+ )-Sensing

      • Edward M. Brown, Naibedya Chattopadhyay, Mei Bai
      Pages 415-442

    9. Calcium and Muscle Disease: Pathophysiology of Calpains and Limb-Girdle Muscular Dystrophy Type 2A (LGMD2A)

      • Yasuko Ono, Shoji Hata, Hiroyuki Sorimachi, Koichi Suzuki
      Pages 443-464

    10. Role of Calcium Channels in Drug Dependence

      • Fernando Rodríguez de Fonseca, Miguel Angel Gorriti, Miguel Navarro
      Pages 465-476

    11. S100 Proteins and Fatty Acid Transport Are Altered in Skin Diseases

      • Gerry Hagens, Georges Siegenthaler
      Pages 477-492

    12. Cancer

      1. Calcium-Binding Proteins in Degenerative and Cancer-Related Diseases of the Eye
        • Ricardo L. Gee, Lalita Subramanian, Teresa M. Walker, Paul R. van Ginkel, Arthur S. Polans
        Pages 493-504
      2. Calcium ATPases Genes and Cell Transformation
        • Patrizia Paterlini-Bréchot, Mounia Chami, Devrim Gozuacik
        Pages 505-519
      3. Interaction of Dimeric S100B(<i>ββ</i>) with the Tumor Suppressor Protein p53: A Model for Ca<sup>2+</sup>-Dependent S100-Target Protein Interactions
        • David J. Weber, Richard R. Rustandi, France Carrier, Danna B. Zimmer
        Pages 521-539
      4. The Interaction of Calmodulin with Novel Target Proteins
        • Kelly Y. Chun, David B. Sacks
        Pages 541-563

    13. Liver Diseases

      1. Type II Citrullinemia (Citrin Deficiency): A Mysterious Disease caused by a Defect of Calcium-Binding Mitochondrial Carrier Protein
        • Keiko Kobayashi, Mikio Iijima, Tomotsugu Yasuda, David S. Sinasac, Naoki Yamaguchi, Lap-Chee Tsui et al.
        Pages 565-587

    14. Neurodegeneration

      1. High Calcium Concentrations, Calpain Activation and Cytoskeleton Remodeling in Neuronal Regeneration after Axotomy
        • M. E. Spira, N. E. Ziv, R. Oren, A. Dormann, D. Gitler
        Pages 589-605

    15. Neurodegenerative Diseases

      1. Genetic Factors and the Role of Calcium in Alzheimer’s Disease Pathogenesis
        • Mervyn J. Monteiro, Stacy M. Stabler
        Pages 607-623
      2. The Role of Intracellular Calcium Signaling in Motoneuron Function and Disease
        • Bernhard U. Keller
        Pages 625-637

  2. Methodological Chapters

    1. Front Matter

      Pages 639-639
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Keywords

About this book

The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world.
The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era.
The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets.
In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches.Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists.
The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

Editors and Affiliations

  • Université Libre de Bruxelles, Belgium

    Roland Pochet

Bibliographic Information

  • Book Title: Calcium: The molecular basis of calcium action in biology and medicine

  • Editors: Roland Pochet, Rosario Donato, Jacques Haiech, Claus Heizmann, Volker Gerke

  • DOI: https://doi.org/10.1007/978-94-010-0688-0

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2000

  • Hardcover ISBN: 978-0-7923-6421-4Published: 30 November 2000

  • Softcover ISBN: 978-0-7923-6422-1Published: 30 November 2000

  • eBook ISBN: 978-94-010-0688-0Published: 28 June 2011

  • Edition Number: 1

  • Number of Pages: XXXIX, 732

  • Topics: Human Genetics, Human Physiology, Biochemistry, general, Nephrology, Diabetes, Neurosciences

  • Industry Sectors: Biotechnology, Pharma

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