Excitation-Contraction Coupling and Cardiac Contractile Force

  • Donald M. Bers

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 237)

Table of contents

  1. Front Matter
    Pages iii-xxiv
  2. Donald M. Bers
    Pages 39-62
  3. Donald M. Bers
    Pages 63-100
  4. Donald M. Bers
    Pages 101-132
  5. Donald M. Bers
    Pages 133-160
  6. Donald M. Bers
    Pages 203-244
  7. Donald M. Bers
    Pages 273-331
  8. Back Matter
    Pages 333-427

About this book

Introduction

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction.
The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).
Excitation-Contraction Coupling and Cardiac Contractile Force &endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Keywords

cardiovascular cardiovascular system cells heart heart muscle smooth muscle

Authors and affiliations

  • Donald M. Bers
    • 1
  1. 1.Department of PhysiologyLoyola University ChicagoMaywoodUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-010-0658-3
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-7158-8
  • Online ISBN 978-94-010-0658-3
  • Series Print ISSN 0166-9842
  • About this book
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