© 1980

Orotic Acid


Table of contents

  1. Front Matter
    Pages i-vii
  2. Orotic Acid: Synthesis, Biochemical Aspects and Physiological Role

    1. Front Matter
      Pages 1-1
    2. Alois Čihák, Werner Reutter
      Pages 3-6
    3. Alois Čihák, Werner Reutter
      Pages 7-13
    4. Alois Čihák, Werner Reutter
      Pages 14-17
    5. Alois Čihák, Werner Reutter
      Pages 18-22
    6. Alois Čihák, Werner Reutter
      Pages 23-25
    7. Alois Čihák, Werner Reutter
      Pages 26-30
    8. Alois Čihák, Werner Reutter
      Pages 31-34
    9. Alois Čihák, Werner Reutter
      Pages 35-40
    10. Alois Čihák, Werner Reutter
      Pages 41-45
  3. Back Matter
    Pages 49-118

About this book


This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's milk 75 years ago by Biscaro and Belloni in Italy. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of these pyrimidines is well regulated. Disturbance of the biosynthetic pathway or trapping of individual pyrimidine nucleotides may lead to severe metabolic and structural alterations of cells. Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro­ cesses, mentioned in Chapters 8 and 9. At the end of this overview a Bibliography in an alphabetical order with 673 references may give further insight in this topic.


biosynthesis carbohydrate cells efficiency enzymes fatty liver glycogen growth growth factor liver molecule myocardial infarction organ regulation therapy

Authors and affiliations

  1. 1.Institute of Organic Chemistry and BiochemistryCzechoslovakia Academy of Sciences PragueCzechoslovakia
  2. 2.Institut für Molekularbiologie und Biochemie der Freien UniversitätBerlinGermany

Bibliographic information

  • Book Title Orotic Acid
  • Authors A. Cihák
    W. Reutter
  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1980
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-85200-294-0
  • Softcover ISBN 978-94-009-8045-7
  • eBook ISBN 978-94-009-8043-3
  • Edition Number 1
  • Number of Pages VII, 118
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Hepatology
  • Buy this book on publisher's site
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