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© 1984

Safety and efficacy of radiopharmaceuticals

  • Knud Kristensen
  • Elisabeth Nørbygaard
Book

Part of the Developments in Nuclear Medicine book series (DNUM, volume 4)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Development of the Documentation for Efficacy and Safety of Radiopharmaceuticals

    1. Front Matter
      Pages 1-1
    2. Knud Kristensen, Elisabeth Norbygaard
      Pages 3-4
    3. Gopal Subramanian, J. G. McAfee, R. F. Schneider
      Pages 5-43
    4. Jiri Cifka
      Pages 44-65
    5. Gertrude Pfeiffer
      Pages 66-84
    6. Per O. Bremer
      Pages 85-98
    7. Charles Fallais, Francis Smal
      Pages 99-106
    8. Maurizio Villa
      Pages 107-116
    9. Yves Cohen
      Pages 140-157
    10. Hans Detlev Roedler
      Pages 158-178
    11. Harriet Dige-Petersen
      Pages 191-202
    12. Rolf de Jong, Wim B. Huising
      Pages 203-212
    13. David H. Keeling
      Pages 240-250
    14. Bente Pedersen
      Pages 251-262

About this book

Introduction

Safety and efficacy of radiopharmaceuticals are elements of great importance in nuclear medicine. Since the first meeting in 1965 in Oak Ridge with the title Radiopharmaceuticals tremendous developments have taken place. In 1965 the whole technetium-99m area was just in its very beginning. Safety and efficacy of the non-radioactive pharmaceuticals have attracted great attention during the last 10 years and so have similar aspects of radiopharmaceuticals during the later years. Regulatory agencies are extending their work also to the preparation of radiopharmaceuticals at hospitals and to requirements for registration of radiopharmaceuticals. In a fast developing field there might be tendencies to confrontation between interests and there have certainly been some tendencies to put undue restrictions on the use of radio­ pharmaceuticals due to the lack of understanding between the industry and the regulatory authorities and between regulatory authorities and hospitals. Much of this may have been due to lack of information and certainly is due to the lack of fundamental scientific knowledge in many radiopharmaceutical aspects. A fast and safe introduction of new radio­ pharmaceuticals and the proper handling of these requires a lot of development work, but also an understanding of how general principles from the non-radioactive drug field may be sensibly transformed into the radiopharmaceutical area. It may even require compromises between requirements for safety in different areas such as radiation protection and pharmaceutical aspects.

Keywords

clinical trial dosimetry drug ethics kinetics pharmacokinetics pharmacology radiation research

Editors and affiliations

  • Knud Kristensen
    • 1
  • Elisabeth Nørbygaard
    • 1
  1. 1.The Isotope-PharmacyThe National Board of HealthCopenhagenDenmark

Bibliographic information

  • Book Title Safety and efficacy of radiopharmaceuticals
  • Editors Knud Kristensen
    Elisabeth Nørbygaard
  • Series Title Developments in Nuclear Medicine
  • DOI https://doi.org/10.1007/978-94-009-6753-3
  • Copyright Information Springer Science+Business Media B.V. 1984
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89838-609-7
  • Softcover ISBN 978-94-009-6755-7
  • eBook ISBN 978-94-009-6753-3
  • Edition Number 1
  • Number of Pages , 336
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Nuclear Medicine
    Pharmacology/Toxicology
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology
Nuclear Medicine
Radiology