Fundamental Fault in Hypertension

1. The Role of the Central Nervous System: Mediation or Initiation?

   1. Arterial Baroreflexes in Human Beings

      • Giuseppe Mancia, Alberto Zanchetti

      Pages 190-206

   2. Possible Mechanism of Protection from Renal Hypertension by Anteroventral Third Ventricle (AV3V) Lesions: Role of Renal Afferent Nerves

      • L. T. Mahoney, J. R. Haywood, R. Correy, N. P. Patel, A. K. Johnson, M. J. Brody

      Pages 207-212

   3. Neuronal Systems and their Impact on Blood Pressure Regulation

      • Walter Lovenberg, Donald Kuhn, Judith Juskevich

      Pages 213-227

   4. Brain Catecholaminergic Mechanisms and Hypertension

      • Wybren de Jong, Dirk H. G. Versteeg

      Pages 228-234

   5. Continuous Intra-Arterial Blood Pressure Recording in Human Hypertension

      • Giuseppe Mancia, Alberto Ferrari, Luisa Gregorini, Gianfranco Parati, Piero Cioffi, Marco Di Rienzo et al.

      Pages 235-250

   6. Role of Vasopressin in Blood Pressure Regulation Through its Modulatory Effect on Baroreceptor Reflex

      • Yutaki Imai, Peter L. Nolan, Colin I. Johnston

      Pages 251-260

2. Altered Hemodynamics: A Cause or a Consequence?

   1. Front Matter

      Pages 261-261

      PDF

   2. Controversies in the Research on Hemodynamic Mechanisms in the Development of Hypertension

      • Stevo Julius

      Pages 263-275

   3. The Role of the Heart in Hypertension

      • Robert C. Tarazi

      Pages 276-295

   4. Structural Change in the Blood Vessel Wall

      • Rosemary D. Bevan, John A. Bevan

      Pages 296-306

3. How is the Renin System Involved?

   1. Front Matter

      Pages 307-307

      PDF

   2. Is there a Fault in the Renin-Angiotensin System in Essential Hypertension?

      • John D. Swales

      Pages 309-318

   3. Biological Significance of Active and Inactive Renin in Hypertensive Patients

      • P. Lijnen, R. Fagard, J. Staessen, L. Verschueren, A. Amery

      Pages 319-330

   4. The Relation of Plasma Renin Substrate to Blood Pressure in Essential Hypertension

      • W. Gordon Walker, Hiroshi Saito

      Pages 331-340

   5. On Renin Substrate and Hypertension

      • Mohinder P. Sambhi

      Pages 341-346

The fundamental fault in hypertension is unknown. Calling it a fundamental fault, indeed, tacitly begs the question: Is there one fundamental fault, or are there several that are interlinked or interdependent? A simple yes or no answer cannot be offered. This volume is not designed to survey the up-to-date recent advances in research on hypertension, nor intended to provide provisional an­ swers to the so many unknowns in this topic. It is, in fact, an attempt to articulate questions that are worth asking, given the license of an unhibited, albeit disci­ plined, inquiry. The range of expression varies from dogmatic opinion to a declared speculation. Is the primary abnormality an excessive sodium and reduced potassium intake over generations? Or is it hormonal excess, deficiency, imbalance or altered synthesis of abnormal forms? Does the nervous system playa role of active initiation or only of passive maintenance in the genesis of hypertension? Is the heart only a pump acting in concert with the happenings to the vasculature trying to provide adequate flow in the face of vasconstriction induced by neural or humoral factors, or does it sometimes become the culprit by pumping blood flow in excess of demand and thus initiating hypertrophic changes in blood vessels, or by assuming the role of an endocrine organ and being the source of a hormone with influence on cellular transport of sodium and on vasomotor tone? Is an elusive and mysterious fault in the kidney, the primary basis of all of the above

• arterial pressure
• blood pressure
• heart
• hemodynamics
• hypertension

• Division of Hypertension, Department of Medicine, UCLA, Sepulveda, USA

  Mohinder P. Sambhi

• San Fernando Valley Medical Program, Veterans Administration Medical Center, Sepulveda, USA

  Mohinder P. Sambhi

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