© 1987

Arterial and Venous Systems in Essential Hypertension

  • M. E. Safar
  • G. M. London
  • A. Ch. Simon
  • Y. A. Weiss

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 63)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Small arteries and the concept of resistance

  3. Low pressure system and the concept of venous distensibility

  4. Large vessels and the concept of arterial compliance

    1. Front Matter
      Pages 103-103
    2. Edward D. Frohlich, Franz H. Messerli
      Pages 105-114
    3. Alain Simon, Jaime Levenson
      Pages 115-131
    4. A. P. Avolio
      Pages 133-152
  5. Regional circulations

    1. Front Matter
      Pages 165-165
    2. Pierre A. Wicker, Robert C. Tarazi
      Pages 167-180
    3. M. E. Safar, St. Laurent, J. A. Bouthier
      Pages 181-195
    4. P. W. De Leeuw, W. H. Birkenhäger
      Pages 197-210
    5. Y. A. Weiss, G. H. London, M. E. Safar
      Pages 211-219

About this book


The hemodynamic mechanisms of hypertension are often limited to the study of three dominant parameters: blood pressure, cardiac output and vascular resis­ tance. Accordingly, the development of hypertension is usually analyzed in terms of a 'struggle' between cardiac output and vascular resistance, resulting in the classical pattern of normal cardiac output and increased vascular resistance, thus indicating a reduction in the caliber of small arteries. However, during the past years, the clinical management of hypertension has largely modified these simple views. While an adequate control of blood pressure may be obtained with antihypertensive drugs, arterial complications may occur, involving mainly the coronary circulation and suggesting that several parts of the cardiovascular system are altered in hypertension. Indeed, disturbances in the arterial and the venous system had already been noticed in animal hypertension. The basic assumption in this book is that the overall cardiovascular system is involved in the mechanisms of the elevated blood pressure in patients with hypertension: not only the heart and small arteries, but also the large arteries and the venous system. For that reason, the following points are emphasized. First, the cardiovascular system in hypertension must be studied not only in terms of steady flow but also by taking into account the pulsatile components of the heart and the arterial systems. Second, arterial and venous compliances are altered in hypertension and probably reflect intrinsic alterations of the vascular wall.


cardiovascular cardiovascular system circulation hypertension kidney

Editors and affiliations

  • M. E. Safar
    • 1
  • G. M. London
  • A. Ch. Simon
  • Y. A. Weiss
  1. 1.Diagnostic Center, Department of Internal MedicineHôpital BroussaisParisFrance

Bibliographic information

  • Book Title Arterial and Venous Systems in Essential Hypertension
  • Editors Michel Emile Safar
  • Series Title Developments in Cardiovascular Medicine
  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1987
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89838-857-2
  • Softcover ISBN 978-94-010-7983-9
  • eBook ISBN 978-94-009-3303-3
  • Series ISSN 0166-9842
  • Edition Number 1
  • Number of Pages VIII, 323
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology