Separations for Biotechnology 2

  • D. L. Pyle

Table of contents

  1. Front Matter
    Pages i-xii
  2. Plenary Paper

  3. Cell Disruption and Removal of Insolubles

  4. Concentration Processes

    1. Front Matter
      Pages 103-103
    2. J. B. Chaudhuri, D. L. Pyle
      Pages 112-121
    3. Charles L. Cooney, Ulrich Holeschovsky, Gopal Agarwal
      Pages 122-131
    4. Kathleen Fletcher, Sheryl Deley, Robert J. Fleischaker Jr, Ian T. Forrester, Anthony C. Grabski, W. Nick Strickland
      Pages 142-151
    5. Karel Goossens, Leo Van Biesen
      Pages 162-171
    6. Tim A. J. Harris, Simi Khan, Bryan G. Reuben, Tina Shokoya
      Pages 172-180
    7. J. G. Huddleston, K. W. Ottomar, D. Ngonyani, J. A. Flanagan, A. Lyddiatt
      Pages 181-190
    8. Barbara Krajewska, Maciej Leszko, Wiesława Zaborska
      Pages 191-199
    9. Sudesh B. Mohan, Julia M. Malhotra, Andrew Lyddiatt
      Pages 200-209
    10. Gordon W. Niven, Susan J. Smith, Peter G. Scurlock, Anthony T. Andrews
      Pages 210-216
    11. K. Schügerl, W. Degener, P. v. Frieling, L. Handojo, I. Kirgios
      Pages 238-244
    12. T. Sirman, D. L. Pyle, A. S. Grandison
      Pages 245-254
  5. High Resolution Separations

    1. Front Matter
      Pages 255-255
    2. Howard A. Chase
      Pages 257-264
    3. Steven J. Burton, James C. Pearson, David L. Stewart
      Pages 265-274
    4. J. L. Casillas, J. L. Garrido, J. Aracil, M. Martinez, F. Addo-Yobo, C. N. Kenney
      Pages 285-294
    5. Ezio D’ Addario, Michele Patrissi, Maurizio Masi, Giuseppe Storti, Sergio Carra’
      Pages 305-314
    6. Andrew J. Daugulis, Charlene P. Wight, Mattheus F. A. Goosen, Kelly E. Chesney
      Pages 315-324
    7. Nicholas M. Draeger, Howard A. Chase
      Pages 325-334
    8. T. Franco, B. A. Andrews, O. Cascone, C. Hodgson, A. T. Andrews, J. A. Asenjo
      Pages 335-344
    9. S. Harsa, D. L. Pyle, C. A. Zaror
      Pages 345-354
    10. R. J. Hinton, T. Atkinson, C. P. Price, M. D. Scawen
      Pages 355-363
    11. Michael J. Hudson, Simon Hemmings, M. S. Verrall
      Pages 364-370
    12. Peter R. Levison, Stephen E. Badger, David W. Toome, Diane Carcary, Edward T. Butts
      Pages 381-389
    13. Julie Miller, Helen C. Morris, Christopher P. Price, T. Atkinson, Peter M. Hammond
      Pages 400-408
    14. Graham L. Skidmore, Howard A. Chase
      Pages 418-427

About this book


The challenge of bioseparations is to isolate and purify identified products from the dilute product broth produced from cell culture. Innovation in bioseparations technology is increasingly driven by the requirements imposed by the growing importance of production on a process scale of injectable-grade products, and economic pressures to improve the efficiency of downstream processing. As in other areas of technical change, science does not necessarily precede new technology: progress results from a complex and messy mixture of advances in understanding, ingenious ideas, novel techniques and chance discoveries. What is certain is that close interaction between academics and practitioners, biological scientists and process engineers is needed to solve the problems of bioseparations. The Second International Conference on Separations for Biotechnology at Reading, UK, in September 1990 set out to provide a critical multidisciplinary forum for the discussion of bioseparations. This volume contains the papers presented at the meeting. The meeting was organised around six themes with oral and poster presentations on the science and practice of bioseparations technology, and the same structure has been kept for this book. We have also included the texts of the keynote review paper by Professor Alan Michaels and the introductory review papers specially commissioned for the conference. Within each part of this book the review paper is followed by the contributed papers grouped alphabetically by their first author. All the original papers published here were accepted for publication after scientific refereeing.


Downstream Processing Expression Fermentation archaebacteria biotechnology chromatography cloning filtration polymer protein reaction tissue ultrafiltration virus

Editors and affiliations

  • D. L. Pyle
    • 1
  1. 1.Biotechnology GroupUniversity of ReadingUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1990
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6839-0
  • Online ISBN 978-94-009-0783-6
  • Buy this book on publisher's site