© 2013

Peroxisomes and their Key Role in Cellular Signaling and Metabolism

  • Luis A. del Río
  • Describes the central role played in cellular signaling by peroxisomes from different origins

  • Provides an up-to-date information on the function and metabolism of peroxisomes from human, animal, fungal and plant origin

  • Provides updated information on the metabolic interconnection and cross-talk of peroxisomes with other cell compartments

  • Describes the key cellular function played by peroxisomes as cell generators of important signaling molecules

  • Covers the role played by peroxisomes in human health, aging and disease


Part of the Subcellular Biochemistry book series (SCBI, volume 69)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Michael Schrader, Sandra Grille, H. Dariush Fahimi, Markus Islinger
    Pages 1-22
  3. Marc Fransen, Marcus Nordgren, Bo Wang, Oksana Apanasets, Paul P. Van Veldhoven
    Pages 45-65
  4. Charlotte Odendall, Jonathan C. Kagan
    Pages 67-75
  5. Parimal Misra, Navin Viswakarma, Janardan K. Reddy
    Pages 77-99
  6. Isabelle Weinhofer, Markus Kunze, Sonja Forss-Petter, Johannes Berger
    Pages 101-110
  7. Alex Costa, Ilaria Drago, Michela Zottini, Paola Pizzo, Tullio Pozzan
    Pages 111-133
  8. Ida J. van der Klei, Marten Veenhuis
    Pages 135-152
  9. Nicole Linka, Frederica L. Theodoulou
    Pages 169-194
  10. Navneet Kaur, Jiying Li, Jianping Hu
    Pages 195-211
  11. Luisa M. Sandalio, María Rodríguez-Serrano, María C. Romero-Puertas, Luis A. del Río
    Pages 231-255
  12. Gretchen M. Spiess, Bethany K. Zolman
    Pages 257-281
  13. Francisco J. Corpas, Juan B. Barroso, José M. Palma, Luis A. del Río
    Pages 283-298
  14. Back Matter
    Pages 347-350

About this book


Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid β-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid α-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer’s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid β-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores.

Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance.


Cellular signaling Fungi and plants Humans and animals Metabolism and signaling Peroxisomes

Editors and affiliations

  • Luis A. del Río
    • 1
  1. 1., Depto. Bioquímica, Biología Celular yEstación Experimental del Zaidín, CSICGranadaSpain

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