© 2013

Tight Junctions in Cancer Metastasis

  • Tracey A. Martin
  • Wen G. Jiang

Part of the Cancer Metastasis - Biology and Treatment book series (CMBT, volume 19)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Elaine A. McSherry, Mark B. Owens, Ann M. Hopkins
    Pages 1-27
  3. Anna-Maria Tokes, Zsuzsa Schaff, Attila Marcell Szasz, Janina Kulka
    Pages 29-64
  4. María Isabel Larre, Catalina Flores-Maldonado, Marcelino Cereijido
    Pages 65-80
  5. Klaus Ebnet, Benjamin F. Brinkmann, Daniel Kummer, Steve Misselwitz, Swetha S. D. Peddibhotla, Hüseyin Tuncay
    Pages 119-129
  6. Tracey A. Martin, Mark Haynes, Ninaard Answare, Gareth Brown, Wen G. Jiang
    Pages 131-148
  7. Frédéric Hollande, Marina Papin
    Pages 149-167
  8. Lorenza González-Mariscal, Mónica Díaz-Coránguez, Miguel Quirós
    Pages 197-246
  9. Cláudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenço, Fernando Augusto Soares
    Pages 263-274
  10. Jane Lane, Tracey A. Martin, Wen G. Jiang
    Pages 291-301
  11. Back Matter
    Pages 303-313

About this book


There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.


Cancer Diagnostics Metastasis Therapeutics Tight Junctions

Editors and affiliations

  • Tracey A. Martin
    • 1
  • Wen G. Jiang
    • 2
  1. 1.Cardiff UniversityInstitute of Cancer & GeneticsCardiffUnited Kingdom
  2. 2.Cardiff UniversityInstitute of Cancer & GeneticsCardiffUnited Kingdom

Bibliographic information

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