© 2013

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

  • Silvia Mandel


  • Unique concept of the book in terms of predictive diagnostics, targeted preventive measures and individualised algorithms for treatment of neurodegenerative diseases

  • Very useful information for professionals

  • Unlimited audience


Part of the Advances in Predictive, Preventive and Personalised Medicine book series (APPPM, volume 2)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Part I

  3. Part II

  4. Part III

    1. Front Matter
      Pages 93-93
    2. Iris Grossman, Michael W. Lutz, Donna G. Crenshaw, Ann M. Saunders, Ornit Chiba-Falek, William K. Gottschalk et al.
      Pages 141-160
    3. Peter A. LeWitt, Bertrand R. Huber, Jing Zhang
      Pages 161-184
  5. Part IV

    1. Front Matter
      Pages 185-185
  6. Part V

    1. Front Matter
      Pages 203-203
    2. Chen Benkler, Daniel Offen, Eldad Melamed, Tamar Amit, Silvia Mandel, Moussa B. H. Youdim et al.
      Pages 235-274
  7. Part VI

    1. Front Matter
      Pages 275-275
    2. Andrea Döring, Caspar F. Pfueller, Friedemann Paul, Jan Dörr
      Pages 277-299

About this book


The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments.

This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.


Neurodegenerative diseases Neuropsychiatric diseases Personalized treatment Predictive diagnosis Preventive measures

Editors and affiliations

  • Silvia Mandel
    • 1
  1. 1., Molecular PharmacologyTechnion, Institute of TechnologyHaifaIsrael

Bibliographic information

  • Book Title Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future
  • Editors Silvia Mandel
  • Series Title Advances in Predictive, Preventive and Personalised Medicine
  • Series Abbreviated Title Advances in Predictive, Preventive
  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-94-007-5865-0
  • Softcover ISBN 978-94-007-9295-1
  • eBook ISBN 978-94-007-5866-7
  • Series ISSN 2211-3495
  • Series E-ISSN 2211-3509
  • Edition Number 1
  • Number of Pages XVIII, 398
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biomedicine, general
    Health Promotion and Disease Prevention
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
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From the reviews:

“This book provides an overview of up-to-date literature on existing and potential future predictive, preventive, and personalized therapeutic approaches to neurodegenerative diseases. It is a useful resource for clinicians and researchers interested in the current status of research findings and their potential future applications in this field.” (Nilufer Ertekin-Taner, Doody’s Book Reviews, October, 2013)