Morphofunctional Aspects of Tumor Microcirculation

  • Domenico┬áRibatti

Table of contents

  1. Front Matter
    Pages 1-1
  2. Domenico Ribatti
    Pages 1-3
  3. Domenico Ribatti
    Pages 5-19
  4. Back Matter
    Pages 6-6

About this book

Introduction

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodelling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

Keywords

Angiogenesis Antiangiogenesis Endothelium Microcirculation Tumor growth

Authors and affiliations

  • Domenico┬áRibatti
    • 1
  1. 1.Policlinico, Department of Human AnatomyUniversity of Bari Medical SchoolBariItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-4936-8
  • Copyright Information Springer Science+Business Media Dordrecht 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-4935-1
  • Online ISBN 978-94-007-4936-8
  • About this book
Industry Sectors
Biotechnology
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Pharma