Endoplasmic Reticulum Stress in Health and Disease

  • Patrizia Agostinis
  • Samali Afshin

Table of contents

  1. Front Matter
    Pages 1-1
  2. Cellular Responses to ER Stress

    1. Front Matter
      Pages 1-1
    2. Sandra JM Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis, Afshin Samali
      Pages 3-22
    3. Jared Q Gerlach, Shashank Sharma, Kirk J Leister, Lokesh Joshi
      Pages 23-39
    4. Tom Verfaillie, Richard Jäger, Afshin Samali, Patrizia Agostinis
      Pages 41-73
    5. Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo, Cristina Fasolato
      Pages 75-106
    6. Tim Vervliet, Santeri Kiviluoto, Geert Bultynck
      Pages 107-142
    7. Danielle E. Read, Ananya Gupta, Karen Cawley, Sanjeev Gupta
      Pages 143-161
    8. María Salazar, Sonia Hernández-Tiedra, Mar Lorente, Guillermo Velasco
      Pages 163-184
    9. Mohammed Bensellam, Patrick Gilon, Jean-Christophe Jonas
      Pages 185-211
  3. ER stress in physiological & pathological conditions

    1. Front Matter
      Pages 205-205
    2. Fumihiko Urano, Bryan O’Sullivan-Murphy
      Pages 215-230
    3. Abhishek D. Garg, Agnieszka Kaczmarek, Dmitri V. Krysko, Peter Vandenabeele
      Pages 257-279
    4. Michal F. Tomczak, Arthur Kaser, Richard S. Blumberg
      Pages 281-298
    5. Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson, Fumihiko Urano
      Pages 299-321
    6. Han-Jou Chen, Jackie de Belleroche
      Pages 323-337
    7. Jody Groenendyk, Marek Michalak
      Pages 339-355
    8. Stéphanie Lhomond, Eric Chevet
      Pages 357-382
    9. Ethel R. Pereira, Amanda M. Preston, Linda M. Hendershot
      Pages 383-412
    10. Abhishek D. Garg, Dmitri V. Krysko, Jakub Golab, Peter Vandenabeele, Patrizia Agostinis
      Pages 413-428
    11. Laurence A. Booth, Nichola Cruickshanks, Yong Tang, M. Danielle Bareford, Hossein A. Hamed, Paul B. Fisher et al.
      Pages 429-445
  4. Back Matter
    Pages 430-430

About this book


The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome.  This book primarily focuses on the pathophysiology of ER stress.  It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and  metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit.  Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.


Cell Death Diseases ER stress Inflammation Unfolded Protein response

Editors and affiliations

  • Patrizia Agostinis
    • 1
  • Samali Afshin
    • 2
  1. 1.Dept Molec Cell BioK.U. LeuvenB-3000 LeuvenBelgium
  2. 2.School of Natural Science, Department of BiochemistryNUI GalwayGalwayIreland

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