Midkine: From Embryogenesis to Pathogenesis and Therapy

  • Mine Ergüven
  • Takashi Muramatsu
  • Ayhan Bilir

Table of contents

  1. Front Matter
    Pages i-ix
  2. General Aspects of Midkine

    1. Front Matter
      Pages 1-1
    2. Takashi Muramatsu
      Pages 3-13
    3. Sheng Yao, Christoph Winkler
      Pages 15-28
    4. Sara L. Nordin, Arne Egesten
      Pages 29-39
    5. Yiping Huang, Edward A. Ratovitski
      Pages 41-52
    6. Stefan Sommerschuh, Michael Kirchner, Nicole Gliese
      Pages 53-67
    7. Malgorzata Krzystek-Korpacka, Malgorzata Matusiewicz
      Pages 69-85
  3. Midkine and Inflammation

    1. Front Matter
      Pages 87-87
    2. Nuray Yazıhan, Mehtap Kacar Kocak, Ethem Akcıl
      Pages 89-101
    3. Hisako Muramatsu, Kiyoko Maruyama, Naoki Ishiguro
      Pages 103-109
  4. Midkine and the Cardiovascular System

    1. Front Matter
      Pages 111-111
    2. Mitsuru Horiba, Kenji Kadomatsu
      Pages 113-124
    3. Kenji Kadomatsu
      Pages 125-130
    4. Tomoki Kosugi, Kenji Kadomatsu
      Pages 131-140
  5. Midkine and the Nervous System

    1. Front Matter
      Pages 141-141
    2. Hideyuki Takeuchi
      Pages 143-151
    3. Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita, Yasuhiro Kumai
      Pages 153-163
    4. Eiji Shimizu, Daisuke Matsuzawa
      Pages 165-170
  6. Midkine and the Urogenital System, Reproduction and Aging

    1. Front Matter
      Pages 171-171
    2. Waichi Sato, Kenji Kadomatsu
      Pages 173-182
    3. Masayasu Yamada, Yuuki Isaji, Shuntaro Ikeda
      Pages 183-193
    4. Yutaka Osuga, Yasushi Hirota, Kaori Koga, Osamu Yoshino, Tetsuya Hirata
      Pages 195-202
    5. Hisako Muramatsu, Peng Zou, Takashi Muramatsu
      Pages 203-210
    6. Astrid Liedert, Thorsten Schinke, Anita Ignatius, Michael Amling
      Pages 211-221
  7. Midkine and Cancer

    1. Front Matter
      Pages 223-223
    2. Yoshifumi Takei, Kenji Kadomatsu
      Pages 225-236
    3. Masatoshi Tagawa, Kiyoko Kawamura, Ling Yu, Yuji Tada, Kenzo Hiroshima, Hideaki Shimada
      Pages 237-246
    4. Jerome Kerzerho, Florence Anne Castelli, Bernard Maillère
      Pages 247-258
    5. Zongbing You
      Pages 259-271
    6. Li Cheng Dai, Xing Yao, Jing Zhong
      Pages 273-282
    7. Özgür Kemik, Ahu Sarbay Kemik, A. Cumhur Dülger
      Pages 305-311
    8. Tadashi Kaname, Kumiko Yanagi, Hiroki Maehara
      Pages 313-319
  8. Back Matter
    Pages 321-336

About this book


Carl Edward Sagan’s (1934-1996) one of the famous quatation was “Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.“ From past to date, well-known molecules, enzymes, proteins, lipids and carbonhydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgetten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named “Midkine” This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.


Development and reproduction Disease Midkine Survival and resistance Therapy

Editors and affiliations

  • Mine Ergüven
    • 1
  • Takashi Muramatsu
    • 2
  • Ayhan Bilir
    • 3
  1. 1.Faculty of Medicine, Faculty of BiochemistryYeni Yüzyıl UniversityIstanbulTurkey
  2. 2., Department of Health ScienceAichi Gakuin UniversityNisshinJapan
  3. 3., Department of Histology and EmbryologyIstanbul University Faculty of MedicineIstanbulTurkey

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