© 2012

Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

  • Tony Harris

Part of the Subcellular Biochemistry book series (SCBI, volume 60)

Table of contents

  1. Front Matter
    Pages I-VI
  2. How AJs Evolved

    1. Front Matter
      Pages 7-7
  3. How Cadherins and Catenins Interact to Assemble AJs

    1. Front Matter
      Pages 37-37
    2. Noboru Ishiyama, Mitsuhiko Ikura
      Pages 39-62
    3. Deborah Leckband, Sanjeevi Sivasankar
      Pages 63-88
    4. Sergey Troyanovsky
      Pages 89-108
  4. How AJs Interface with Other Cellular Machinery

    1. Front Matter
      Pages 109-109
    2. Siew Ping Han, Alpha S. Yap
      Pages 111-135
    3. Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori, Yoshimi Takai
      Pages 137-170
    4. Abbye E. McEwen, David E. Escobar, Cara J. Gottardi
      Pages 171-196
  5. How AJs Affect Cell Behaviour and Multicellular Development

    1. Front Matter
      Pages 223-223
    2. Sandrine Etienne-Manneville
      Pages 225-249
    3. Annalisa Letizia, Marta Llimargas
      Pages 251-277
    4. Stephen T. Armenti, Jeremy Nance
      Pages 279-299
    5. Rudolf Winklbauer
      Pages 301-320
  6. How AJs Affect Tissue Homeostasis and Disease

    1. Front Matter
      Pages 357-357

About this book


Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs.  Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. 

In this volume, internationally recognized experts review AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development.  AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases.  This book addresses major questions encompassing AJ biology.

- How did AJs evolve?
- How do cadherins and catenins interact to assemble AJs and mediate adhesion?
- How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
- How do AJs affect cell behaviour and multicellular development?
- How can abnormal AJ activity lead to disease?

Valuable for both newcomers and experts in the field, this book offers a comprehensive resource for the research laboratory and a teaching tool for advanced undergraduate and graduate courses in cell and developmental biology.


adherens junctions animal tissues cell adhesion disease multicellular development

Editors and affiliations

  • Tony Harris
    • 1
  1. 1., Cell and Systems BiologyUniversity of TorontoTorontoCanada

Bibliographic information

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