© 2012

Phosphoinositides I: Enzymes of Synthesis and Degradation

  • Tamas Balla
  • Matthias Wymann
  • John D. York

Part of the Subcellular Biochemistry book series (SCBI, volume 58)

Table of contents

  1. Front Matter
    Pages 1-1
  2. Shane Minogue, Mark G. Waugh
    Pages 1-24
  3. Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan, Richard Anderson
    Pages 25-59
  4. Aurelie Gresset, John Sondek, T. Kendall Harden
    Pages 61-94
  5. Matthias Wymann
    Pages 111-181
  6. Alessandra Ghigo, Fulvio Morello, Alessia Perino, Emilio Hirsch
    Pages 183-213
  7. Jennifer M. Dyson, Clare G. Fedele, Elizabeth M. Davies, Jelena Becanovic, Christina A. Mitchell
    Pages 215-279
  8. Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal, Clare G. Fedele, Christina A. Mitchell, Nicholas R. Leslie
    Pages 281-336
  9. Tamas Balla, Matthias Wymann, John D. York
    Pages 337-337
  10. Back Matter
    Pages 334-334

About this book


Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

The two volumes on “Phosphoinositides” provide a concise overview of the latest developments in the field of phosphoinositide hemostasis and function, and provide introductory background and extensions into unexplored territory.


PI 3-kinase PTEN kinase phosphatase phosphoinositide

Editors and affiliations

  • Tamas Balla
    • 1
  • Matthias Wymann
    • 2
  • John D. York
    • 3
  1. 1., NICHDNational Institutes of HealthBethesdaUSA
  2. 2., Cancer- and ImmunobiologyUniversity of BaselBaselSwitzerland
  3. 3., Pharmacology and Cancer BiologyDuke University Medical CenterDurhamUSA

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