Aging Research in Yeast

  • Michael Breitenbach
  • S. Michal Jazwinski
  • Peter Laun

Part of the Subcellular Biochemistry book series (SCBI, volume 57)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Michael Breitenbach, Peter Laun, S. Michal Jazwinski
    Pages 1-12
  3. May T. Aung-Htut, Anita Ayer, Michael Breitenbach, Ian W. Dawes
    Pages 13-54
  4. Michael Breitenbach, Peter Laun, J. Richard Dickinson, Andrea Klocker, Mark Rinnerthaler, Ian W. Dawes et al.
    Pages 55-78
  5. Valter D. Longo, Paola Fabrizio
    Pages 101-121
  6. M. Werner-Washburne, Sushmita Roy, George S. Davidson
    Pages 123-143
  7. Peter W. Piper
    Pages 145-159
  8. John P. Aris, Laura K. Fishwick, Michelle L. Marraffini, Arnold Y. Seo, Christiaan Leeuwenburgh, William A. Dunn Jr.
    Pages 161-186
  9. William C. Burhans, Martin Weinberger
    Pages 187-206
  10. Peter Laun, Sabrina Büttner, Mark Rinnerthaler, William C. Burhans, Michael Breitenbach
    Pages 207-232
  11. Christian Q. Scheckhuber, Andrea Hamann, Diana Brust, Heinz D. Osiewacz
    Pages 233-250
  12. George L. Sutphin, Brady A. Olsen, Brian K. Kennedy, Matt Kaeberlein
    Pages 251-289
  13. Armin Rashidi, Thomas B.L. Kirkwood, Daryl P. Shanley
    Pages 315-330
  14. David Amberg, Jane E. Leadsham, Vasillios Kotiadis, Campbell W. Gourlay
    Pages 331-352
  15. Back Matter
    Pages 353-365

About this book


This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.


Aging Cell Death Cell Quality Control Sacchromyces cerevisiae Yeast

Editors and affiliations

  • Michael Breitenbach
    • 1
  • S. Michal Jazwinski
    • 2
  • Peter Laun
    • 3
  1. 1., Department of Cell BiologyUniversity of SalzburgSalzburgAustria
  2. 2., Tulane Center for Aging and Department oTulane University Health Sciences CenterNew OrleansUSA
  3. 3., Department of Cell BiologyUniversity of SalzburgSalzburgAustria

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