© 2012

Epigenetic Epidemiology

  • Karin B. Michels

Table of contents

  1. Front Matter
    Pages i-xii
  2. Karin B. Michels
    Pages 1-3
  3. Peter A. Jones, Gangning Liang
    Pages 5-20
  4. Ludovic Barault, Rebecca C. Rancourt
    Pages 37-56
  5. E. Andrés Houseman
    Pages 57-76
  6. Gavin Kelsey
    Pages 77-103
  7. Karin B. Michels, Robert A. Waterland
    Pages 105-116
  8. Nicole Banks, James H. Segars
    Pages 117-136
  9. I. Karen Temple, Jill Clayton-Smith, Deborah J. G. Mackay
    Pages 137-160
  10. Richard Saffery, Ruth Morley, Debra L. Foley
    Pages 161-183
  11. Jean-Pierre Issa
    Pages 185-196
  12. Brock C. Christensen, Carmen J. Marsit, Karl T. Kelsey
    Pages 197-224
  13. Angela Risch, Narek Sarkisyan, David Scherf, Hanna Jacobsson, Wolfgang Hagmann, Christoph Plass
    Pages 225-267
  14. Toshikazu Ushijima, Hideyuki Takeshima
    Pages 269-288
  15. Caroline Ospelt, Steffen Gay
    Pages 289-305
  16. Rachel L. Miller
    Pages 307-319
  17. Bart P. F. Rutten, Jim van Os
    Pages 343-376
  18. Amanda J. MacFarlane
    Pages 377-400

About this book


The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance.  Epigenetics plays an  important role in shaping who we are and contributes to our prospects of health and disease.  While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components.  The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis.

With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!


Basic Science Epidemiology Epigenetics Human Research Prevention

Editors and affiliations

  • Karin B. Michels
    • 1
  1. 1., Obstetrics and Gynecology Epidemiology DBrigham and Women’s HospitalBostonUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology
Consumer Packaged Goods


From the reviews:

“It aims to be both a primer in epidemiology for epigeneticists and an epigenetics reference for epidemiologists. … the field of epigenetic epidemiology is in ascendency and this textbook provides the first broad foundation for anyone embarking on population-based studies in epigenetic epidemiology. … Any prospective researcher aspiring to address any of the many unanswered fundamental issues in this field would certainly find this book a must useful reference.” (Catherine Potter and Caroline L. Relton, International Journal of Epidemiology, Vol. 41 (1), February, 2012)