Tumor-Associated Fibroblasts and their Matrix

Tumor Stroma

  • Margareta M. Mueller
  • Norbert E. Fusenig

Part of the The Tumor Microenvironment book series (TTME, volume 4)

Table of contents

  1. Front Matter
    Pages 1-1
  2. The Tumor Microenvironment

    1. Front Matter
      Pages 1-1
  3. Stromal Cell Diversity

    1. Front Matter
      Pages 21-21
    2. H. Peter Rodemann, Hans-Oliver Rennekampff
      Pages 23-36
    3. Boris Hinz, Ian A. Darby, Giulio Gabbiani, Alexis Desmoulière
      Pages 37-74
    4. Olivier De Wever, Astrid De Boeck, Pieter Demetter, Marc Mareel, Marc Bracke
      Pages 75-89
    5. Arne Bartol, Anna M. Laib, Hellmut G. Augustin
      Pages 91-110
  4. The Tumor ECM

    1. Front Matter
      Pages 125-125
    2. Florence Brellier, Ruth Chiquet-Ehrismann
      Pages 145-158
    3. Helen C. M. Cooney, William M. Gallagher
      Pages 159-174
    4. Julie Lecomte, Anne Masset, Dylan R. Edwards, Agnès Noël
      Pages 175-193
  5. Tumor Modulating-Fibroblast Interactions

    1. Front Matter
      Pages 195-195
    2. Masayuki Shimoda, Kieran Mellody, Akira Orimo
      Pages 245-255
    3. Carina Hellberg, Carl-Henrik Heldin
      Pages 257-265
    4. Mary Helen Barcellos-Hoff, David H. Nguyen
      Pages 267-282
  6. Tumor-Modulating ECM Interactions

    1. Front Matter
      Pages 283-283
    2. Stacey L. Thomas, Sandra A. Rempel
      Pages 301-346
    3. Christie J. Avraamides, Judith A. Varner
      Pages 347-360
    4. Hans Petter Eikesdal, Raghu Kalluri
      Pages 361-380
  7. Therapeutic Application/Targeting

    1. Front Matter
      Pages 381-381
    2. Christian Rupp, Helmut Dolznig, Christian Haslinger, Norbert Schweifer, Pilar Garin-Chesa
      Pages 383-401
    3. Debbie Liao, Ralph A. Reisfeld
      Pages 403-418
    4. Katharina Frey, Dario Neri
      Pages 419-450
  8. Back Matter
    Pages 438-438

About this book


During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on “Tumor-associated fibroblasts and their matrix” as part of the series on “Tumor-Microenvironment” is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy.


cancer associated fibroblasts novel targets for tumor therapy tumor microenvironment tumor specific ECM tumor-stroma interactions

Editors and affiliations

  • Margareta M. Mueller
    • 1
  • Norbert E. Fusenig
    • 2
  1. 1.Villingen-SchwenningenGermany
  2. 2.HeidelbergGermany

Bibliographic information

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