© 2011

Molecular Basis of Health and Disease


Table of contents

  1. Front Matter
    Pages 1-1
  2. Undurti N. Das
    Pages 1-10
  3. Undurti N. Das
    Pages 15-100
  4. Undurti N. Das
    Pages 153-173
  5. Undurti N. Das
    Pages 181-238
  6. Undurti N. Das
    Pages 239-275
  7. Undurti N. Das
    Pages 333-357
  8. Undurti N. Das
    Pages 359-376
  9. Undurti N. Das
    Pages 417-464
  10. Undurti N. Das
    Pages 465-489
  11. Undurti N. Das
    Pages 491-512
  12. Undurti N. Das
    Pages 551-573
  13. Back Matter
    Pages 566-566

About this book


The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.


Metabolic syndrome Obesity Polyunsaturated fatty acids Rheumatology Type 2 diabetes mellitus

Authors and affiliations

  1. 1.UND Life ScienceShaker HeightsUSA

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