© 2011

Sarcopenia – Age-Related Muscle Wasting and Weakness

Mechanisms and Treatments

  • Gordon S. Lynch

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Gordon S. Lynch
    Pages 1-7
  3. Josep M. Argilés, Sílvia Busquets, Marcel Orpi, Roberto Serpe, Francisco J. López-Soriano
    Pages 9-35
  4. Carlos B. Mantilla, Gary C. Sieck
    Pages 37-54
  5. Alexander Cristea, David E. Vaillancourt, Lars Larsson
    Pages 55-74
  6. Stephen E. Alway, Parco M. Siu
    Pages 173-206
  7. Aaron P. Russell, Bertrand Lèger
    Pages 207-221
  8. Kathleen O’Connell, Philip Doran, Joan Gannon, Pamela Donoghue, Kay Ohlendieck
    Pages 259-287
  9. René Koopman, Lex B. Verdijk, Luc J. C. van Loon
    Pages 289-315
  10. Donato A. Rivas, Roger A. Fielding
    Pages 333-371
  11. John A. Faulkner, Christopher L. Mendias, Carol S. Davis, Susan V. Brooks
    Pages 373-391
  12. Chris D. McMahon, Thea Shavlakadze, Miranda D. Grounds
    Pages 393-418
  13. Craig McFarlane, Mridula Sharma, Ravi Kambadur
    Pages 419-447

About this book


Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.


Aging Neuromuscular biology Skeletal muscle Sports medicine Therapy

Editors and affiliations

  • Gordon S. Lynch
    • 1
  1. 1., Department of PhysiologyThe University of MelbourneMelbourneAustralia

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods