Signal Transduction in Cancer Metastasis

  • Wen-Sheng Wu
  • Chi-Tan Hu

Part of the Cancer Metastasis - Biology and Treatment book series (CMBT, volume 15)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Wen-Sheng Wu, Jia-Ru Wu
    Pages 1-8
  3. Laure Voisin∗, Stéphanie Duhamel∗, Sylvain Meloche
    Pages 25-40
  4. Alexey Shiryaev, Marijke Van Ghelue, Ugo Moens
    Pages 41-76
  5. Alessio Giubellino, Praveen R. Arany
    Pages 77-102
  6. Wen-Sheng Wu, Jia-Ru Wu
    Pages 103-118
  7. Moulay A. Alaoui-Jamali, Krikor Bijian, Panagiota Toliopoulos
    Pages 137-155
  8. Pingyu Zhang, Patrick A. Zweidler-McKay
    Pages 157-174
  9. Lydia W.T. Cheung, Carman K.M. Ip, Alice S.T. Wong
    Pages 225-253
  10. Cécile Laurent, Jérôme Couturier, Xavier Sastre-Garau, Laurence Desjardins, Emmanuel Barillot, Sophie Piperno-Neumann et al.
    Pages 255-263
  11. Back Matter
    Pages 283-285

About this book


The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.


Activation Cancer metastasis Endoplasmatisches Reticulum Integrin Migration Ras-ERK1/2 MAP signal cascade Receptor tyrosine kinase molecular mechanisms proteins signal transduction tissue

Editors and affiliations

  • Wen-Sheng Wu
    • 1
  • Chi-Tan Hu
    • 2
  1. 1.Tzu-Chi University, College of MedicineInstitute of medical biotechnologyHualienTaiwan R.O.C.
  2. 2.Buddhist Tzu-Chi General Hospital, Department of MedicineResearch Center for HepatologyHualienTaiwan R.O.C.

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 2010
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-90-481-9521-3
  • Online ISBN 978-90-481-9522-0
  • Series Print ISSN 1568-2102
  • Buy this book on publisher's site
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