Functional and Structural Proteomics of Glycoproteins

  • Raymond Owens
  • Joanne Nettleship

Table of contents

  1. Front Matter
    Pages i-x
  2. Weston B. Struwe, Eoin F.J. Cosgrave, Jennifer C. Byrne, Radka Saldova, Pauline M. Rudd
    Pages 1-38
  3. T. Shantha Raju, David M. Knight, Robert E. Jordan
    Pages 39-58
  4. René Ranzinger, Kai Maaß, Thomas Lütteke
    Pages 59-90
  5. Lakshmi Krishnamoorthy, Lara K. Mahal
    Pages 91-102
  6. Sasha Singh, Morten Thaysen Andersen, Judith Jebanathirajah Steen
    Pages 103-125
  7. Thomas A. Bowden, Elizabeth E. Fry
    Pages 159-180
  8. Back Matter
    Pages 181-181

About this book

Introduction

It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.

Keywords

Glycans Glycobiology Glycomics Glycoproteins Glycoproteomics

Editors and affiliations

  • Raymond Owens
    • 1
  • Joanne Nettleship
    • 2
  1. 1.Oxford Protein Production FacilityOxfordUnited Kingdom
  2. 2.Oxford Protein Production FacilityOxfordUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-90-481-9355-4
  • Copyright Information Springer Science+Business Media B.V. 2011
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-90-481-9354-7
  • Online ISBN 978-90-481-9355-4
  • About this book
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