© 2010

Endotoxins: Structure, Function and Recognition

  • Xiaoyuan Wang
  • Peter J. Quinn

Part of the Subcellular Biochemistry book series (SCBI, volume 53)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Part I Structure and Properties of Endotoxins

    1. Front Matter
      Pages 1-1
    2. Xiaoyuan Wang, Peter J. Quinn
      Pages 3-25
    3. Xiaoyuan Wang, Chan Zhang, Feng Shi, Xiaoqing Hu
      Pages 27-51
    4. K. Brandenburg, A.B. Schromm, T. Gutsmann
      Pages 53-67
    5. Alba Silipo, Antonio Molinaro
      Pages 69-99
    6. Susan M. Richards, Kristi L. Strandberg, John S. Gunn
      Pages 101-122
    7. Lei Wang, Quan Wang, Peter R. Reeves
      Pages 123-152
    8. Anne F. McGettrick, Luke A.J. O’Neill
      Pages 153-171
  3. Infection, Treatment and Immunity

    1. Front Matter
      Pages 185-185
    2. Samuel M. Moskowitz, Robert K. Ernst
      Pages 241-253
    3. Sunil A. David, Diptesh Sil
      Pages 255-283
    4. Christopher B. Fox, Martin Friede, Steven G. Reed, Gregory C. Ireton
      Pages 303-321
    5. Jean-Sebastien Rachoin, Christa A. Schorr, R. Phillip Dellinger
      Pages 323-338
    6. Russell W. Carlson, L. Scott Forsberg, Elmar L. Kannenberg
      Pages 339-386
    7. G. Erbs, A. Molinaro, J.M. Dow, M.-A. Newman
      Pages 387-403

About this book


Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.


Antigen Sepsis bacteria infection infectious vaccine

Editors and affiliations

  • Xiaoyuan Wang
    • 1
  • Peter J. Quinn
    • 2
  1. 1.Dept. BiochemistryJiangnan UniversityWuxi, JiangsuChina, People's Republic
  2. 2.European Southern Observatory (ESO)GarchingGermany

Bibliographic information

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From the reviews:

“The book consists of two parts that include 17 chapters prepared by an international team of well_ known experts. … The book is well prepared. There are many good quality photos, graphs, and pictures. Each chapter ends with a base reference, and there is a subject index at the end of the book. … very useful for many researchers in the field of biochemistry, biotechnology, immunology, and medicinal chemistry. This book can also be a useful tool for teachers and students of colleges and universities.” (G. Ya. Wiederschain, Biochemistry, Vol. 76 (5), May, 2011)