© 2011

A Handbook of Transcription Factors

  • Timothy R. Hughes


  • Soup-to-nuts overview not provided by any other book

  • Objective, high-level, genome-based viewpoint, with subsidiary examples, rather than “paradigm by anecdote”

  • Combines in-depth analysis of molecular biology literature with computational-based large-scale analyses


Part of the Subcellular Biochemistry book series (SCBI, volume 52)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Aswin Sai Narain Seshasayee, Karthikeyan Sivaraman, Nicholas M. Luscombe
    Pages 7-23
  3. Lisa Stubbs, Younguk Sun, Derek Caetano-Anolles
    Pages 75-94
  4. Thomas R. Bürglin
    Pages 95-122
  5. Keith Pardee, Aleksandar S. Necakov, Henry Krause
    Pages 123-153
  6. Yair Field, Eilon Sharon, Eran Segal
    Pages 193-204
  7. Charles Vinson, Raghunath Chatterjee, Peter Fitzgerald
    Pages 205-222
  8. Seth Frietze, Peggy J. Farnham
    Pages 261-277
  9. Juan M. Vaquerizas, Asifa Akhtar, Nicholas M. Luscombe
    Pages 279-295
  10. Back Matter
    Pages 297-306

About this book


Transcription factors are - in the most common use of the term - proteins that possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes in proximity to the binding site. Transcription factors are the primary interface between the cell and the genome, and in aggregate control not only regulation of transcription but also genome organization, and play a central role in many aspects of physiology and evolution. This book will provide a reference for the major aspects of transcription factor biochemistry, function, and evolution. Contents will range from a general catalogue of known transcription factor classes, origins and evolution of transcription factor types, and mechanisms of interaction with chromatin, the nuclear scaffold, and RNA polymerase.

Editors and affiliations

  • Timothy R. Hughes
    • 1
  1. 1., Centre for Cellular and Biomolecular ResUniversity of TorontoTorontoCanada

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods