© 2010

Calorie Restriction, Aging and Longevity

  • Arthur V. Everitt
  • Suresh I. S. Rattan
  • David G. le Couteur
  • Rafael de Cabo

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Calorie Restriction in Different Species

    1. Front Matter
      Pages 1-1
    2. Arthur V. Everitt, Leonie K. Heilbronn, David G. Le Couteur
      Pages 15-41
    3. Matthew W. Rosenbaum, Bradley J. Willcox, D. Craig Willcox, Makoto Suzuki
      Pages 43-53
    4. Ilhem Messaoudi, Jennifer E. Young, Ricki J. Colman, April M. Handy, George S. Roth, Donald K. Ingram et al.
      Pages 55-78
    5. Luc Poirier, Rafael de Cabo, Sige Zou
      Pages 79-95
    6. Min Wei, Federica Madia, Rafael de Cabo, Valter D. Longo
      Pages 97-109
    7. Stephen J. Simpson, David Raubenheimer
      Pages 111-122
  3. Biochemical and Metabolic Mechanisms of Calorie Restriction

    1. Front Matter
      Pages 123-123
    2. Brian J. Merry, Catherine E. Ash
      Pages 125-139
    3. Brian J. Morris
      Pages 141-175
    4. Edward L. Spangler, Jeffrey Long, Bennett Kelley-Bell, Marshall Miller, Robin K. Minor, Rafael de Cabo
      Pages 177-190
    5. David G. Le Couteur, David A. Sinclair, Victoria C. Cogger, Aisling C. McMahon, Alessandra Warren, Arthur V. Everitt et al.
      Pages 191-216
    6. Arthur V. Everitt, Holly M. Brown-Borg, David G. Le Couteur, Andrzej Bartke
      Pages 217-232
    7. Suresh I.S. Rattan, Dino Demirovic
      Pages 233-245
  4. Calorie Restriction in the Clinical Setting

    1. Front Matter
      Pages 247-247
    2. Krista A. Varady
      Pages 249-261
    3. Anna Csiszar, Rafael de Cabo, Zoltan Ungvari
      Pages 263-277

About this book


Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life.

Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem?

Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.


Diabetes Drosophila Endoplasmatisches Reticulum ageing aging cancer nutrition obesity oxidative stress stress therapy

Editors and affiliations

  • Arthur V. Everitt
    • 1
  • Suresh I. S. Rattan
    • 2
  • David G. le Couteur
    • 3
  • Rafael de Cabo
    • 4
  1. 1.SydneyAustralia
  2. 2.University of AarhusAarhusDenmark
  3. 3.SydneyAustralia
  4. 4.National Institute on Aging, Gerontology Research CenterNational Institute of HealthBaltimoreUSA

Bibliographic information

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