An up-and-coming therapeutical tool

  • Francesco Cecconi
  • Marcello D'Amelio

Table of contents

  1. Front Matter
    Pages i-x
  2. Virve Cavallucci, Marcello D’Amelio
    Pages 1-26
  3. Elisabetta Ferraro, Claudia Fuoco, Flavie Strappazzon, Francesco Cecconi
    Pages 27-39
  4. Laura Mondragón, Mar Orzáez, Anna Gortat, Monica Sancho, Angel Messeguer, María Jesús Vicent et al.
    Pages 75-94
  5. Takashi Ito, Stephen W. Schaffer, Junichi Azuma
    Pages 119-135
  6. Maria Pascale, Alessandra Rosati, Michelina Festa, Anna Basile, Morena d’Avenia, Antonia Falco et al.
    Pages 137-146
  7. Marzia Pennati, Marco Folini, Nadia Zaffaroni
    Pages 147-168
  8. Anne Laure Rérole, Anne Laure Joly, Dominique Thuringer, Carmen Garrido
    Pages 169-202
  9. Yuki Kuwano, Imed-Eddine Gallouzi, Myriam Gorospe
    Pages 203-220
  10. Sang Eun Park, Young Hyun Yoo
    Pages 221-236
  11. Tetsuhiro Tsuruma, Hidekaz Kameshima, Yuji Iwayama, Toshihiko Torigoe, Yoshihiko Hirohashi, Noriyuki Sato et al.
    Pages 305-320
  12. Back Matter
    Pages 321-322

About this book


"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome.

The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases.

The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis.

This book will be a valuable resource for researchers investigating the role of apoptosome-dependent cell death in cancer and other diseases, for researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance and for physicians using chemotherapeutic agents. Additionally, this book will be an important educational source for PhD students and MD students specializing in molecular and cell biology, and to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of programmed cell death.


Activation Apoptosome apoptosis cell biology regulation siRNA

Editors and affiliations

  • Francesco Cecconi
    • 1
  • Marcello D'Amelio
    • 2
  1. 1.Dipto. BiologiaUniversità di Roma, Tor VergataRomaItaly
  2. 2.IRCCSFondazione Santa LuciaRomaItaly

Bibliographic information

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Oncology & Hematology
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