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SUMO Regulation of Cellular Processes

  • Van G. Wilson
Book
  • 9.2k Downloads

Table of contents

  1. Front Matter
    Pages i-ix
  2. Molecular Functions

    1. Front Matter
      Pages 11-11
    2. Van G. Wilson
      Pages 1-10
    3. Jorge A. Iñiguez-Lluhí
      Pages 13-40
    4. Vasupradha Vethantham, James L. Manley
      Pages 41-57
    5. David Wotton, Jacqueline C. Merrill
      Pages 59-76
    6. Nicola Zilio, Helle D. Ulrich
      Pages 77-96
    7. Christopher Ptak, Richard W. Wozniak
      Pages 97-116
    8. Mark Benson, Jorge A. Iñiguez-Lluhí, Jeffrey Martens
      Pages 117-136
    9. Donald D. Anderson, Patrick J. Stover
      Pages 137-149
  3. Cell Growth Regulation

    1. Front Matter
      Pages 151-151
    2. Debaditya Mukhopadhyay, Mary Dasso
      Pages 153-169
    3. Amanda C. Nottke, Monica P. Colaiácovo
      Pages 171-185
    4. Adeline F. Deyrieux, Van G. Wilson
      Pages 187-199
    5. Lyndee L. Scurr, Sebastian Haferkamp, Helen Rizos
      Pages 201-216
    6. Kiyohiko Hatake, Ryoko Kuniyoshi, Yuko Mishima, Yasuhito Terui
      Pages 217-230
  4. Diseases

    1. Front Matter
      Pages 231-231
    2. Dina B. Anderson, Helena Cimarosti, Jeremy M. Henley
      Pages 233-251
    3. Jason S. Lee*, Hee June Choi*, Sung Hee Baek
      Pages 253-272
    4. Jixin Zhong, Ping Yang, Feili Gong, Cong-Yi Wang
      Pages 273-299
    5. Erwin Pauws, Philip Stanier
      Pages 301-313
    6. Adeline F. Deyrieux, Van G. Wilson
      Pages 315-329
  5. Back Matter
    Pages 331-339

About this book

Introduction

Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions.

Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention.

While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.

Keywords

DNA Translation cellular processes molecular mechanisms post-translational modification proteins regulation

Editors and affiliations

  • Van G. Wilson
    • 1
  1. 1.College StationU.S.A.

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