Overview
Synthetic and unique publication on adverse events of a new and fast-growing class of medicines
Multidisciplinary interest (biomedical, public health, biologics producers for human therapy)
Downloadable data sheets enclosed for rapid multi-entry search and consultation?
Includes supplementary material: sn.pub/extras
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Table of contents (59 chapters)
Keywords
About this book
This monograph gathers and evaluates data on adverse events (AEs) associated specifically with those “biomedicines” – monoclonal antibodies, fusion proteins, and cytokines – that have recently entered therapeutic use in humans. All AEs observed when using each member of this new drug class are covered, with a view to improving understanding of pathogenesis, facilitating prevention, monitoring, and control, and contributing to the development of better drugs that provide benefits while minimizing risk. Further aspects here examined include the role of drug mechanisms of action and immunogenicity in relation to AEs outcome and induction of systemic syndromes. Additional data on AEs in off-label treatments are also considered.
Electronic data sheets, downloadable from Springer Extra Materials platform, include more detailed safety data as well as additional basic information on product characteristics, pre- and post-marketing AEs classified according to frequency, and system/organ targeting. Data on excipients and selected information on drug interactions and associations are also provided. Adverse Events with Biomedicines: Prevention Through Understanding will serve as a detailed, practical guideline to this important new area, which demands the attention of clinicians, immunologists, oncologists, allergologists, public health professionals, and drug companies.
Reviews
From the reviews:
“This is a comprehensive review of existing biological therapeutics and their associated toxicities. … This is a thorough and detailed book, written for experts. … this book is more suitable for researchers in this area and for individuals involved in the regulation or testing of biological drugs. … This is a unique source of detailed information on biological drugs. I would recommend it to anyone interested in this field of research.” (Mitchell R. McGill, Doody’s Book Reviews, March, 2014)Authors and Affiliations
About the author
Giuseppe Tridente is currently Professor Emeritus of Immunology at the University of Verona, where he was Dean of the Medical Faculty, founder of the Institute of Immunological Sciences, and Director of the Department of Pathology. In 1992 he founded and directed the “Green Channel” Veneto Regional Centre of Surveillance on Adverse Events to Vaccines. His research, mainly devoted to immunopathology, include experimental oncology, tumor immunology, histocompatibility and transplantation, pathophysiology of the thymus, HIV, and adverse events following immunization. He has 146 publications listed on MEDLINE and is also the author of the first Italian textbook on immunology and immunopathology (1979).
Bibliographic Information
Book Title: Adverse Events with Biomedicines
Book Subtitle: Prevention Through Understanding
Authors: Giuseppe Tridente
DOI: https://doi.org/10.1007/978-88-470-5313-7
Publisher: Springer Milano
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Italia 2014
Hardcover ISBN: 978-88-470-5312-0Published: 20 December 2013
Softcover ISBN: 978-88-470-5848-4Published: 04 May 2017
eBook ISBN: 978-88-470-5313-7Published: 09 December 2013
Edition Number: 1
Number of Pages: XXX, 633
Topics: Biomedicine general, Medicine/Public Health, general, Pharmacy
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Health & Hospitals, Pharma