© 2010

Cardiorenal Syndrome

Mechanisms, Risk and Treatment

  • Adel E. Berbari
  • Giuseppe Mancia

Table of contents

  1. Front Matter
    Pages i-xv
  2. Chronic Kidney Disease and Cardiovascular Disease Interrelationships

    1. Front Matter
      Pages 1-1
    2. Mohammad Sarraf, Amirali Masoumi, Robert W. Schrier
      Pages 15-34
  3. Crosstalk between the Cardiovascular System and the Kidney

    1. Front Matter
      Pages 35-35
    2. Marta Ruiz-Ortega, Raquel Rodrigues-Díez, Sandra Rayego, Raul R. Rodrigues-Díez, Carolina Lavoz, Esther Civantos et al.
      Pages 49-63
  4. Chronic Kidney Disease as a Risk for Cardiovascular Disease

    1. Front Matter
      Pages 65-65
    2. Josè A. García-Donaire, Luis M. Ruilope
      Pages 67-79
    3. Rigas G. Kalaitzidis, Pranav Dalal, George L. Bakris
      Pages 117-130
    4. Manjula Kurella Tamura, Tara I. Chang
      Pages 131-144
  5. Spectrum of Cardiovascular Disease in Chronic Kidney Disease

    1. Front Matter
      Pages 159-159
    2. Frank A. Benedetto, Francesco Perticone, Carmine Zoccali
      Pages 175-187
    3. Mario F. Rubin, Raymond R. Townsend
      Pages 205-215

About this book


Accelerated cardiovascular disease is a frequent complication of chronic kidney disease. Individuals with evidence of renal functional impairment are more likely to die of cardiovascular events than to progress to end stage renal disease.

This relationship, which has been termed the cardiorenal syndrome, exists whether impairment of renal function is a consequence of primary renal parenchymal or primary heart disease.

The mechanisms underlying the cardiorenal syndrome result from a complex interaction of traditional and uremia related cardiovascular risk factors. Prevention and management of cardiovascular disease include aggressive control of traditional risk factors as well novel approach to prevent or reverse uremia related processes.

Chronic kidney disease with a worldwide prevalence of 10% in the general population is emerging as a major public health priority. Renal dysfunction is associated with a high risk for cardiovascular complications. The relationship between renal insufficiency and cardiovascular disease, termed the cardiorenal syndrome exists whether impairment of renal function is a consequence of primary renal parenchymal disease or primary heart disease.

This book provides a comprehensive update analysis of our current understanding of the cardiorenal syndrome, including epidemiology,  pathophysiologic mechanisms, and therapeutic approaches.


Chronic kidney disease cardiorenal syndorme cardiovascular cardiovascular disease hypertension inflammatory markers related cv risk factors uremia

Editors and affiliations

  • Adel E. Berbari
    • 1
  • Giuseppe Mancia
    • 2
  1. 1.Department of Internal MedicineAmerican University of Beirut Medical CenterBeirutLebanon
  2. 2.Clinica Medica Department of Clinical Medicine and PreventionUniversity of Milano-Bicocca San Gerardo HospitalMonza, MilanItaly

Bibliographic information

  • Book Title Cardiorenal Syndrome
  • Book Subtitle Mechanisms, Risk and Treatment
  • Editors Adel E. Berbari
    Giuseppe Mancia
  • DOI
  • Copyright Information Springer-Verlag Milan 2010
  • Publisher Name Springer, Milano
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-88-470-1462-6
  • Softcover ISBN 978-88-470-5609-1
  • eBook ISBN 978-88-470-1463-3
  • Edition Number 1
  • Number of Pages XV, 396
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


From the reviews:

“The first book to bring together information on this important and recently named entity, cardiorenal syndrome. … Nephrologists, cardiologists, and trainees in both specialties can benefit from the information presented in this book … . The book presents a novel concept regarding the structural and functional similarities between vascular smooth muscle cells and glomerular mesangial cells. … This is an important contribution since it is the first one to comprehensively address this frontier between nephrology and cardiology.” (Mony Fraer, Doody’s Review Service, April, 2011)