© 2007

Neurodegeneration in Multiple Sclerosis

  • Massimo Filippi
  • Marco Rovaris
  • Giancarlo Comi

Part of the Topics in Neuroscience book series (TOPNEURO)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Background

    1. Front Matter
      Pages 1-1
    2. E. Capello, A. Uccelli, M. Pizzorno, G.L. Mancardi
      Pages 3-9
    3. L. Leocani, G. Comi
      Pages 11-20
  3. MRI Techniques to Assess Neurodegeneration

    1. Front Matter
      Pages 21-21
    2. W. Rashid, D.T. Chard, D.H. Miller
      Pages 23-35
    3. M. Neema, V.S.R. Dandamudi, A. Arora, J. Stankiewicz, R. Bakshi
      Pages 37-45
    4. M. Inglese, Y. Ge, R.I. Grossman
      Pages 47-53
    5. Y. Ge, M. Law, M. Inglese, R.I. Grossman
      Pages 55-64
    6. M. Rovaris, E. Perego, M. Filippi
      Pages 65-74
    7. N. De Stefano
      Pages 75-83
    8. M. A. Rocca, M. Filippi
      Pages 85-104
  4. Evaluation of MRI Outcomes

    1. Front Matter
      Pages 105-105
    2. M. P. Sormani, M. Filippi
      Pages 107-112
    3. I. Aban, G. Cutter
      Pages 113-125
    4. K. Mouridsen, L. Østergaard
      Pages 127-149
  5. Lessons from Other Neurodegenerative Diseases

    1. Front Matter
      Pages 151-151
    2. G. B. Frisoni
      Pages 153-161
    3. M. Mascalchi
      Pages 163-181
    4. S. Gnanapavan, G. Giovannoni
      Pages 183-207

About this book


In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic reliability and to monitor the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy as to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is dramatically changing our understanding of how MS causes irreversible disability. Written by world-renowned scientists, the volume is indispensable for anybody working in this field.


Alzheimer Alzheimer’s disease Expanded Disability Status Scale brain magnetization trasfer ratio neurophysiology normal-appearing grey matter perception physiology

Editors and affiliations

  • Massimo Filippi
    • 1
  • Marco Rovaris
    • 1
  • Giancarlo Comi
    • 2
  1. 1.Neuroimaging Research Unit Department of NeurologyScientific Institute and University Ospedale San RaffaeleMilanItaly
  2. 2.Department of NeurologyScientific Institute and University Ospedale San RaffaeleMilanItaly

About the editors

Dr. Massimo Filippi was born in 1961, took his Graduation in Medicine in 1986 and his Post-Degree Graduation in Neurology in 1990. His research activity has always been focussed on the use of MR-based technology to improve our understanding of how neurological diseases determine progressive accumulation of irreversible physical disability and cognitive impairment.

Dr. Filippi is member of various Scientific Societies and, in some of them, he covered or is covering institutional roles. He is also member of the Editorial Boards of many international scientific journals and acts as a reviewer on a regular basis for several others. He is author or co-author of more than 450 scientific papers published on peer-reviewed journals.

Dr. Filippi is currently Dierctor of the Neuroimaging Research Unit (NRU), Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, where he is also Non-Tenured Professor of Clinical Neurology. From 2005 he is also Director of the NMR Unit, Centro "S. Maria Nascente" IRCCS Fondazione Don Gnocchi, Milan.

Bibliographic information

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From the reviews:

"This book is to ‘provide a complete and up-to-date overview of the technical, methodological, and clinical issues related to the application of MR imaging in MS trials of neurodegeneration.’ … the strength of this compact book would be its value as a compilation of material that is not so much novel as it is difficult to find in a single volume. … It will provide a convenient reference resource for MS investigators interested in the current status of neurodegeneration imaging studies in MS … ." (American Journal of Neuroradiology, Vol. 29, October, 2008)