Radiopharmaceuticals for Therapy

1. Looking Ahead: New Radiopharmaceutical Strategies for Therapeutic Applications

   1. Front Matter

      Pages 293-293

      PDF

   2. Moving Forward: Expected Opportunities for the Development of New Therapeutic Agents Based on Nanotechnologies

      • F. F. (Russ) Knapp, Ashutosh Dash

      Pages 295-322

   3. Translation of Radiopharmaceuticals from Bench to Bedside: Regulatory and Manufacturing Issues

      • F. F. (Russ) Knapp, Ashutosh Dash

      Pages 323-343

2. Back Matter

   Pages 345-347

   PDF

This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation.  Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy.  In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.

• Molecular nuclear medicine
• Nuclear medicine
• Protontherapy
• Radionuclide therapy
• Therapeutic radiopharmaceuticals
• pharmacotherapy

“Radiopharmaceuticals for Therapy is a well-executed book, divided into 5 parts with the primary focus on the use of radioisotopes for the treatment of disease. … Radiopharmaceuticals for Therapy is a comprehensive volume on radiotherapeutics and unquestionably delivers on its promise to be highly useful to the nuclear medicine professional.” (Dao Le, Journal of Nuclear Medicine, Vol. 58 (9), September, 2017)

“This book … extensively analyzes almost all the aspects related to the development and use of radiopharmaceuticals for therapeutic use. … Their publication is tuned to a multidisciplinary audience ranging from students/residents and practitioners involved in the field, including not only physicians specialized in nuclear medicine … also radiochemists, radiopharmacists, physicists, biologists and others. In addition, it is intended for practitionersand/or students, looking for an upgrade in this charming and ever-expanding field of special cancer therapies.” (Gianluca De Matteis and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 44, 2017)

• Nuclear Security and Isotope Division, Oak Ridge National Laboratory, OAK RIDGE, USA

  F. F. (Russ) Knapp

• Isotope Production and Applications Divn, Bhabha Atomic Research Centre, Mumbai, India

  Ashutosh Dash

F. F. (Russ) Knapp, Jr., Ph.D. Emeritus Program Manager Corporate Fellow ORNL Medical Radioisotope Program Nuclear Security and Isotope Division Bldg. 4501, MS 6229 Oak Ridge National Laboratory (ORNL) PO Box 2008 1 Bethel Valley Road Oak Ridge, TN 37830-6229

Dr. Ashutosh Dash Head, Isotope Production and Applications Division Professor, Homi Bhabha National Institute Bhabha Atomic Research Centre Mumbai, 400085, India

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