Melatonin and Melatonergic Drugs in Clinical Practice

1. Melatonin in Mood Disorders and Agomelatine’s Antidepressant Efficacy

   • Venkataramanujam Srinivasan, Edward C. Lauterbach, Samuel D. Shillcutt, Domenico De Berardis, Preetha Sharone Kuppuswamy, Rahimah Zakaria et al.

   Pages 281-295

2. The Role of Agomelatine in the Treatment of Anxiety Disorders

   • Domenico De Berardis, Nicola Serroni, Marilde Cavuto, Michele Fornaro, Giovanni Martinotti, Francesco Saverio Moschetta et al.

   Pages 297-305

3. Melatonin in the Etiology, Pathophysiology, and Management of Schizophrenia

   • George Anderson, Michael Maes

   Pages 307-320

4. Neurobiology of Monoaminergic Neurotransmission and Antidepressants

   • Francisco López-Muñoz, Cecilio Álamo

   Pages 321-341

5. Melatonergic Drug: Ramelteon and Its Therapeutic Applications in Insomnia

   • Venkataramanujam Srinivasan, Rahimah Zakaria, Timo Partonen, Edward C. Lauterbach, Preetha Sharone Kuppuswamy, Amnon Brzezinski et al.

   Pages 343-352

6. Melatonin’s Neuroprotective Actions on Hippocampal Neurons

   • Pooja Suhalka, Chhavi Sharma, Neha Jaiswal, Piyu Sukhwal, Reena Chittora, Ayushi Jain et al.

   Pages 353-366

7. Jet Lag: Use of Melatonin and Melatonergic Drugs

   • Venkataramanujam Srinivasan, Jarnail Singh, Amnon Brzezinski, Rahimah Zakaria, Samuel D. Shillcutt, Gregory M. Brown

   Pages 367-378

8. Sleep, Melatonin, and Circadian Rhythmicity in Attention Deficit Hyperactivity Disorder

   • Mark A. Snitselaar, Marcel G. Smits

   Pages 379-384

9. Melatonergic Drugs and Their Therapeutic Use in Nasal Polyposis

   • Vural Fidan, Onder Karaaslan

   Pages 385-388

10. Protective Effects of Exogenous Melatonin Against Methotrexate-Induced Intestinal Injury

    • Premila Abraham, Bina Isaac

    Pages 389-402

 

The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson’s disease, Alzheimer’s disease. Additionally, melatonin’s therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin’s antioxidant role in Duchenne’s muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.

• Agomelatine
• Melatonergic drugs
• Melatonin Agonists
• Melatonin in mood disorders
• Melatonin in neurology
• Melatonin in oncology

From the book reviews:

“A review in 29 chapters of the various proven or possible effects of melatonin on physiological states and diseases. The controversial issues of clinical and therapeutic applications are backed up by many references. For those interested in the possible use of Melatonin in sleep and neurological disorders.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (1), September, 2014)

“This book reviews melatonin and its therapeutic clinical application in human disorders. … The book is aimed at a wide audience including students, neurologists, psychiatrists, psychopharmacologists, oncologists, and scientists with an interest in melatonin. … It would be helpful for those in a variety of disciplines, including students, researchers, and clinicians.” (M. Isabel L. Crisostomo, Doody’s Book Reviews, June, 2014)

• Sri Sathya Sai Medical Educational and Research Foundation, An International Medical Sciences Research Center, Coimbatore, India

  V. Srinivasan

• Department of Obstetrics and Gynecology, Hadassah Hebrew-University Medical Center, Jerusalem, Israel

  Amnon Brzezinski

• Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey

  Sukru Oter

• Department of Psychiatry Behavioral Sciences, Mercer University School of Medicine, Macon, Georgia, USA

  Samuel D. Shillcutt

V.Srinivasan Ph.D MAMS
Sri Sathya Sai Medical Educational and Research Foundation
An International Medical Sciences Research Foundation
Prasanthi Nilayam, 40-Kovai Thirunagar, Goldwins, KOVAI
Coimbatore-641014, Tamilnadu, INDIA

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