Systems Biology

The Challenge of Complexity

  • Shigetada Nakanishi
  • Ryoichiro Kageyama
  • Dai Watanabe
Conference proceedings

Table of contents

  1. Front Matter
    Pages i-xv
  2. Dynamics and Complexity of Intercellular Networks

  3. Integrative Mechanism of Intracellular Information Networks

  4. Dysfunction of Information Networks and Related Diseases

    1. Masahiro Nakagawa, Susumu Goyama, Motoshi Ichikawa, Mineo Kurokawa
      Pages 193-198
    2. Yasutaka Niwa, Hiromi Shimojo, Ryoichiro Kageyama
      Pages 199-207
    3. Cornelis J. Weijer
      Pages 209-220
    4. Masahiro Morita, Kentaro Ito, Toru Suzuki, Tadashi Yamamoto
      Pages 229-237
  5. Back Matter
    Pages 243-246

About these proceedings


Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has pursued a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The contributors to this book are leading researchers in the rising field of systems biology. Readers will find not only the most recent advances in research, but also the latest information about interdisciplinary methods and related topics.


Activation Bioinfomatics Biological Network Biological Signaling Immune System Systems Biology genome physiology regulation transcription translation

Editors and affiliations

  • Shigetada Nakanishi
    • 1
  • Ryoichiro Kageyama
    • 2
  • Dai Watanabe
    • 3
  1. 1.Osaka Bioscience InstituteOsakaJapan
  2. 2.Institute for Virus ResearchKyoto UniversityKyotoJapan
  3. 3.Department of Biological Sciences Faculty of Medicine, and Department of Molecular and System BiologyGraduate School of Biostudies Kyoto UniversityKyotoJapan

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