© 1987

Neoplasms of the Liver

  • Kunio Okuda
  • Kamal G. Ishak

Table of contents

  1. Front Matter
    Pages I-IX
  2. Basic Aspects

    1. Front Matter
      Pages 1-1
    2. Nubia Muñoz, Xavier Bosch
      Pages 3-19
    3. Harvey M. Lieberman, Ran Tur-Kaspa, David A. Shafritz
      Pages 21-33
    4. Masao Omata, Osamu Yokosuka, Fumio Imazeki, Kunio Okuda
      Pages 35-45
    5. Jennifer J. Alexander
      Pages 47-56
    6. Masamichi Kojiro, Toshiro Nakashima
      Pages 81-104
    7. Zachary D. Goodman
      Pages 105-125
    8. J. Thomas Stocker, Kamal G. Ishak
      Pages 127-136
    9. Donald B. Rolfes
      Pages 137-142
    10. Shigetaka Sugihara, Masamichi Kojiro
      Pages 143-158
    11. Kamal G. Ishak
      Pages 159-176
    12. Goroku Ohta, Yasuni Nakanuma
      Pages 177-187
    13. Robin A. Bradbear, June W. Halliday, Mark L. Bassett, W. Graham Cooksley, Lawrie W. Powell
      Pages 189-197
  3. Clinical Aspects

    1. Front Matter
      Pages 213-213
    2. Kunio Okuda, Masamichi Kojiro
      Pages 215-226
    3. Norio Sawabu, Nobu Hattori
      Pages 227-237

About this book


Primary liver cancer is a rather unusual malignancy in that the incidence varies tremendously from one geographical area to another. While relatively uncom­ mon in Western countries, it is the most prevalent malignant neoplasm in Southeast Asia, South Africa, and many other regions; in all, the countries in which primary liver cancer is very prevalent account for more than two-thirds of the world's population. In China alone, approximately 100 000 people die every year from primary liver cancer, mostly hepatocellular carcinoma. The incidence is rising in some countries, especially Japan, where it has doubled among males in the past 15 years or so, a staggering and puzzling trend. Since the demonstration of an etiological relationship between hepatitis B virus infection and hepatocellular carcinoma, intensive research has been con­ ducted in an effort to elucidate the role of the virus in hepatocarcinogenesis. Though much progress has been made, a full understanding of the molecular events leading to malignant transformation of the hepatocyte will probably require many more years of rigorous investigation. Chemical carcinogens and several industrial pollutants may also be involved in the etiopathogenesis of neoplastic liver disease.


cancer carcinogenesis carcinoma hepatitis Hepatitis B hepatocellular carcinoma liver liver cancer liver disease pathogenesis

Editors and affiliations

  • Kunio Okuda
    • 1
  • Kamal G. Ishak
    • 2
  1. 1.First Department of MedicineChiba University School of MedicineInohana, Chiba, 280Japan
  2. 2.Department of Hepatic PathologyArmed Forces Institute of PathologyUSA

Bibliographic information

  • Book Title Neoplasms of the Liver
  • Editors Kunio Okuda
    Kamal G. Ishak
  • DOI
  • Copyright Information Springer-Verlag Tokyo 1987
  • Publisher Name Springer, Tokyo
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-4-431-70020-3
  • Softcover ISBN 978-4-431-68351-3
  • eBook ISBN 978-4-431-68349-0
  • Edition Number 1
  • Number of Pages IX, 420
  • Number of Illustrations 243 b/w illustrations, 0 illustrations in colour
  • Topics Hepatology
  • Buy this book on publisher's site
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Internal Medicine & Dermatology