Hereditary Colorectal Cancer

Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan

  • Joji Utsunomiya
  • Henry T. Lynch
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XXIV
  2. General Aspects of Hereditary Colorectal Cancer

    1. Front Matter
      Pages 1-1
    2. Henry T. Lynch, Stephen J. Lanspa, Thomas C. Smyrk, Robert J. Fitzgibbons Jr., Patrice Watson, Bruce M. Boman et al.
      Pages 17-25
    3. Mark Leppert, Yusuke Nakamura, Randall Burt, J. P. Hughes, Wade Samowitz, Scott Woodward et al.
      Pages 27-36
    4. Walter F. Bodmer
      Pages 37-42
  3. Identification, Surveillance, and Management of Polyposis Syndrome

    1. Front Matter
      Pages 43-43
    2. G. Griffioen, H. F. A. Vasen, F. C. A. den Hartog Jager, F. M. Nagengast, H. W. Verspaget, P. Meera Khan et al.
      Pages 57-62
    3. Piotr Krokowicz
      Pages 71-74
    4. Shozo Baba, Masato Tsuchiya, Hiroyuki Machida, Masao Yamada
      Pages 91-96
    5. A. Romania, F. Heyen, D. Jagelman, J. Church, Z. Zakov, I. Lavery et al.
      Pages 97-99
  4. Identification, Surveillance, and Management of Hereditary Nonpolyposis Colorectal Cancer

    1. Front Matter
      Pages 101-101
    2. Stephen J. Lanspa, Henry T. Lynch, Thomas C. Smyrk, Robert J. Fitzgibbons Jr., Patrice Watson, J. X. Jenkins
      Pages 115-117
    3. Patrice Watson, Henry T. Lynch
      Pages 119-126
    4. Mitsuro Chiba, Yukiko Ohyama, Osamu Masamune, Tetsuro Kato, Kazunari Sato, Tomio Narisawa et al.
      Pages 135-141
    5. H. F. A. Vasen, F. C. A. den Hartog Jager, F. M. Nagengast, F. H. Menko, G. J. A. Offerhaus, G. Griffioen
      Pages 143-149
    6. Jens O. Søndergaard, Steffen Bülow, Elsebeth Lynge
      Pages 157-158
    7. Randall W. Burt, D. Timothy Bishop
      Pages 159-162
    8. L. Bertario, P. Sala, P. Spinelli, L. Gennari, G. Ballardini, M. Vidale
      Pages 163-168
    9. Paul Rozen, Zvi Fireman, Elaine Ron
      Pages 169-173
    10. F. A. Macrae, D. J. B. St. John, E. Muir, S. McPherson
      Pages 175-183
    11. Patrick M. Lynch, Rodger J. Winn, Michael J. Wargovich, Bernard Levin
      Pages 185-191
    12. G. Cristofaro, E. di Giulio, P. L. Mingazzini, P. Bufo, S. Senatore, P. M. Lynch et al.
      Pages 193-201
    13. Robert J. Fitzgibbons, Henry T. Lynch, Stephen J. Lanspa, Thomas Smyrk, Bruce Boman, Jane Lynch et al.
      Pages 211-217
    14. Tooru Sakiyama, Youichirou Sakanoue, Yoshio Miki, Masato Kusunoki, Joji Utsunomiya
      Pages 219-224
  5. Chemoprevention of Colorectal Cancer

    1. Front Matter
      Pages 225-225
    2. Martin Lipkin, Paul Rozen
      Pages 227-230
    3. Tomio Narisawa, Masahiro Takahashi, Naoshi Kusaka, Yoshihiko Yamazaki, Hirofumi Koyama, Hitoshi Kotanagi et al.
      Pages 239-248
    4. Hideho Takada, Toshiyuki Minoura, Toshiyuki Takata, Michitomo Sakaguchi, Kazuhiko Yoshioka, Manabu Yamamura et al.
      Pages 249-256
    5. Michael J. Wargovich, Bernard Levin, Patrick Lynch, Hiromichi Sumiyoshi, Allan Baer, Gerald Isbell et al.
      Pages 265-270
    6. Hartley S. Stern, Roger C. Gregoire, Hanoch Kashtan, Teri Berk, W. Robert Bruce
      Pages 283-291

About these proceedings


Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen­ tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino­ genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri­ zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ­ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.


biomolecular genetics classification colorectal cancer genetics markers registries screening cancer classification colorectal cancer DNA gastrointestinal tract genetics molecular genetics mutagen oncology oncovirus pathology tumor

Editors and affiliations

  • Joji Utsunomiya
    • 1
  • Henry T. Lynch
    • 2
  1. 1.Second Department of SurgeryHyogo College of MedicineHyogo, 663Japan
  2. 2.Department of Preventive MedicineCreighton University School of Medicine, Hereditary Cancer CenterOmahaUSA

Bibliographic information

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