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© 2002

Handbook of Glycosyltransferases and Related Genes

  • Naoyuki Taniguchi
  • Koichi Honke
  • Minoru Fukuda
  • Henrik Clausen
  • Kiyoshi Furukawa
  • Gerald W. Hart
  • Reiji Kannagi
  • Toshisuke Kawasaki
  • Taroh Kinoshita
  • Takashi Muramatsu
  • Masaki Saito
  • Joel H. Shaper
  • Kazuyuki Sugahara
  • Lawrence A. Tabak
  • Dirk H. Van den Eijnden
  • Masaki Yanagishita
  • James W. Dennis
  • Koichi Furukawa
  • Yoshio Hirabayashi
  • Masao Kawakita
  • Koji Kimata
  • Ulf Lindahl
  • Hisashi Narimatsu
  • Harry Schachter
  • Pamela Stanley
  • Akemi Suzuki
  • Shuichi Tsuji
  • Katsuko Yamashita
  • Provide comprehensive information on all known glycosyltransferases and their related gene

Book

Table of contents

  1. Front Matter
    Pages II-XVIII
  2. Glucosyltransferase

    1. Front Matter
      Pages 1-1
    2. Yoshio Hirabayashi, Shinichi Ichikawa
      Pages 3-8
  3. Galactosyltransferases

    1. Front Matter
      Pages 9-9
    2. Nancy L. Shaper, Joel H. Shaper
      Pages 11-19
    3. Kiyoshi Furukawa, Henrik Clausen
      Pages 20-26
    4. Thierry Hennet, Eric G. Berger
      Pages 27-32
    5. Koichi Furukawa
      Pages 33-36
    6. Hisashi Narimatsu
      Pages 37-43
    7. Dirk H. Van Den Eijnden, David H. Joziasse
      Pages 44-50
  4. N-Acetylglucosaminyltransferases

    1. Front Matter
      Pages 59-59
    2. Pamela Stanley
      Pages 61-69
    3. Harry Schachter
      Pages 70-79
    4. Yoshitaka Ikeda, Naoyuki Taniguchi
      Pages 80-86
    5. Mari T. Minowa, Suguru Oguri, Aruto Yoshida, Makoto Takeuchi
      Pages 87-93
    6. James W. Dennis
      Pages 94-101
    7. Koichi Honke, Naoyuki Taniguchi
      Pages 102-106
    8. Robert S. Haltiwanger
      Pages 107-113
    9. Minoru Fukuda
      Pages 114-124

About this book

Introduction

The so-called postgenomic research era has now been launched, and the field of gly­ cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl­ transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local­ ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi­ cal investigations.

Keywords

Glycogen Nucleotide carbohydrates enzyme enzymes glycobiology glycoconjugates glycotechnology sulfotransferases

Editors and affiliations

  • Naoyuki Taniguchi
    • 1
  • Koichi Honke
    • 1
  • Minoru Fukuda
    • 2
  • Henrik Clausen
  • Kiyoshi Furukawa
  • Gerald W. Hart
  • Reiji Kannagi
  • Toshisuke Kawasaki
  • Taroh Kinoshita
  • Takashi Muramatsu
  • Masaki Saito
  • Joel H. Shaper
  • Kazuyuki Sugahara
  • Lawrence A. Tabak
  • Dirk H. Van den Eijnden
  • Masaki Yanagishita
  • James W. Dennis
  • Koichi Furukawa
  • Yoshio Hirabayashi
  • Masao Kawakita
  • Koji Kimata
  • Ulf Lindahl
  • Hisashi Narimatsu
  • Harry Schachter
  • Pamela Stanley
  • Akemi Suzuki
  • Shuichi Tsuji
  • Katsuko Yamashita
  1. 1.Department of BiochemistryOsaka University Medical SchoolOsakaJapan
  2. 2.Glycobiology Program, Cancer Research InstituteThe Burnham InstituteLa JollaUSA

Bibliographic information

  • Book Title Handbook of Glycosyltransferases and Related Genes
  • Editors Naoyuki Taniguchi
    Koichi Honke
    Minoru Fukuda
  • DOI https://doi.org/10.1007/978-4-431-67877-9
  • Copyright Information Springer-Verlag Tokyo 2002
  • Publisher Name Springer, Tokyo
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-4-431-70311-2
  • Softcover ISBN 978-4-431-67996-7
  • eBook ISBN 978-4-431-67877-9
  • Edition Number 1
  • Number of Pages XVIII, 670
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Enzymology
    Biochemistry, general
  • Buy this book on publisher's site
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